{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:59:14Z","timestamp":1790866754033,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,29]],"date-time":"2005-06-29T00:00:00Z","timestamp":1120003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to examine the efficacy of vitamin B6 against chromium (Cr)\u2010induced oxidative stress. Adult male albino Wistar rats (100\u2013120 g) were used in this study. Potassium dichromate, a Cr VI compound, was administered at a dose of 127 mg kg<jats:sup>\u22121<\/jats:sup> p.o. Vitamin B6 (pyridoxine hydrochloride) was administered at a dose of 100 mg kg<jats:sup>\u22121<\/jats:sup> p.o. either alone or 12 h prior to Cr or simultaneously with Cr. Chromium treatment induced oxidative stress in the liver as measured by increased lipid peroxidation (LPO) and decreased vitamin C, vitamin E, glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), superoxide dismutase (SOD), glutathione S\u2010transferase (GST) and glutathione reductase (GR). Both pre\u2010 and simultaneous treatments countered Cr\u2010induced oxidative stress; pre\u2010treatment was more effective than concurrent administration. The results demonstrate the antioxidant potential of vitamin B6. 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