{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:24:33Z","timestamp":1779276273793,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T00:00:00Z","timestamp":1134345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Curcumin (diferuoyl methane) from turmeric is a well\u2010known biologically active compound. It has been shown to ameliorate oxidative stress and it is considered to be a potent cancer chemopreventive agent. In our previous study the antioxidative effects of curcumin in cadmium exposed animals were demonstrated. Also manganese exerts protective effects in experimental cadmium intoxication. The present study examined the ability of the manganese complex of curcumin (Mn\u2010curcumin) and curcumin to protect against oxidative damage and changes in trace element status in cadmium\u2010intoxicated male mice. Curcumin or Mn\u2010curcumin were administered at equimolar doses (0.14 mmol\/kg b.w.) for 3 days, by gastric gavages, dispersed in methylcellulose. One hour after the last dose of antioxidants, cadmium chloride (33 \u00b5mol\/kg) was administered subcutaneously. Both curcumin and Mn\u2010curcumin prevented the increase of hepatic lipid peroxidation \u2014 expressed as MDA level, induced by cadmium intoxication and attenuated the Cd\u2010induced decrease of hepatic GSH level. No change in hepatic glutathione peroxidase or catalase activities was found in Cd\u2010exposed mice. A decreased GSH\u2010Px activity was measured in curcumin and Mn\u2010curcumin alone treated mice. Neither curcumin nor Mn\u2010curcumin treatment influenced cadmium distribution in the tissues and did not correct the changes in the balance of essential elements caused by Cd\u2010treatment. The treatment with Mn\u2010curcumin increased the Fe and Mn content in the kidneys of both control and Cd\u2010treated mice and Fe and Cu content in the brain of control mice. In conclusion, regarding the antioxidative action, introducing manganese into the curcumin molecule does not potentiate the studied effects of curcumin. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1124","type":"journal-article","created":{"date-parts":[[2005,12,12]],"date-time":"2005-12-12T12:47:00Z","timestamp":1134391620000},"page":"207-212","source":"Crossref","is-referenced-by-count":49,"title":["The influence of curcumin and manganese complex of curcumin on cadmium\u2010induced oxidative damage and trace elements status in tissues of mice"],"prefix":"10.1002","volume":"26","author":[{"given":"Vladislav","family":"Eybl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Kotyzov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Le\u0161etick\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Bludovsk\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslav","family":"Koutensk\u00fd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,12,12]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"673","volume-title":"Methods of Enzymatic Analysis.","author":"Aebi H","year":"1972"},{"key":"e_1_2_1_3_1","first-page":"349","volume-title":"Phytopharmaceuticals in Cancer Chemoprevention","author":"Aggarwal BB","year":"2005"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2004-6403"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-0456(02)00180-1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2005.04.004"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(92)90282-2"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2003.10.014"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1306.009"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2004.09.041"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.02.019"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2004.08.008"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(85)90673-2"},{"key":"e_1_2_1_14_1","first-page":"444","article-title":"An improved coupled test procedure for glutathione peroxidase (EC 1.11.1.9.) in blood","volume":"12","author":"G\u00fcnzler VA","year":"1974","journal-title":"Z. 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