{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T12:14:23Z","timestamp":1767960863197,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T00:00:00Z","timestamp":1142899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The neuroprotective effects of newly developed oximes (K027, K048) and currently available oximes (obidoxime, HI\u20106) in combination with atropine in rats poisoned with tabun at a sublethal dose (170 \u00b5g kg<jats:sup>\u22121<\/jats:sup> i.m.; 80% of LD<jats:sub>50<\/jats:sub> value) were studied. The tabun\u2010induced neurotoxicity was monitored using a functional observational battery and an automatic measurement of motor activity. The neurotoxicity of tabun was monitored at 24 h and 7 days following tabun challenge. The results indicate that the oxime HI\u20106 in combination with atropine was not able to protect the rats from the lethal effects of tabun. Two non\u2010treated tabun\u2010poisoned rats and one tabun\u2010poisoned rat treated with atropine combined with HI\u20106 died within 2 h. On the other hand, all other tested oximes combined with atropine allowed all the tabun\u2010poisoned rats to survive 7 days following tabun challenge. Both newly developed oximes combined with atropine seem to be sufficiently effective antidotes for a decrease in tabun\u2010induced neurotoxicity in the case of sublethal poisoning although they are not able to eliminate tabun\u2010induced neurotoxicity completely. The neuroprotective efficacy of obidoxime in combination with atropine approached the potency of newly developed oximes but the ability of the oxime HI\u20106 to counteract tabun\u2010induced acute neurotoxicity was significantly lower, especially at 24 h after tabun poisoning. Due to their neuroprotective effects, both newly developed oximes appear to be suitable oximes for the antidotal treatment of acute tabun poisoning. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1137","type":"journal-article","created":{"date-parts":[[2006,3,21]],"date-time":"2006-03-21T12:16:45Z","timestamp":1142943405000},"page":"309-316","source":"Crossref","is-referenced-by-count":7,"title":["A comparison of the potency of newly developed oximes (K027, K048) and commonly used oximes (obidoxime, HI\u20106) to counteract tabun\u2010induced neurotoxicity in rats"],"prefix":"10.1002","volume":"26","author":[{"given":"Ji\u0159\u00ed","family":"Kassa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Kunesova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,3,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"27","article-title":"Tabun \u2014 reappearance 50 years later (in Czech)","volume":"93","author":"Cabal J","year":"1999","journal-title":"Chem. 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