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The aim was to study the effects on spontaneous and stimulus\u2010evoked cortical, and evoked peripheral, nervous activity, to detect any interaction of the metals and any correlation between the changes caused in the spontaneous and stimulus\u2010evoked electrical activity of the primary somatosensory cortical area, and the compound action potential of the tail nerve. In the frequency distribution of the spontaneous cortical activity, a shift to lower frequencies was seen. The cortical responses evoked by whisker or tail stimulation showed an increase of the peak\u2010to\u2010peak amplitude and peak latency on administration of the metals and metal combinations. With the metal combinations, synergism was observed. Correlations found between alterations of the spontaneous and evoked, or between cortical and peripheral, activity were evaluated in terms of mechanism. According to the results, combined exposure to the three heavy metals studied might lead to synergistic action, indicating an increased health risk in settings with exposure to several heavy metals. Copyright \u00a9 2006 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1152","type":"journal-article","created":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T08:06:39Z","timestamp":1150963599000},"page":"374-380","source":"Crossref","is-referenced-by-count":16,"title":["Effects on the central and peripheral nervous activity in rats elicited by acute administration of lead, mercury and manganese, and their combinations"],"prefix":"10.1002","volume":"26","author":[{"given":"Andr\u00e1s","family":"Papp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"Pecze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fcnde","family":"Vez\u00e9r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,22]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(200002)37:2<193::AID-AJIM5>3.0.CO;2-J"},{"key":"e_1_2_1_3_1","first-page":"173","article-title":"Manganese uptake and distribution in the central nervous system (CNS)","volume":"20","author":"Aschner M","year":"1999","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1006\/eesa.1996.0020"},{"key":"e_1_2_1_5_1","first-page":"7.15","volume-title":"Textbook of Pharmacology","author":"Bowman WC","year":"1980"},{"key":"e_1_2_1_6_1","first-page":"131","article-title":"Permeability of the blood\u2013brain barrier to lead","volume":"14","author":"Bradbury MW","year":"1993","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(92)90193-I"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(95)03559-1"},{"key":"e_1_2_1_9_1","first-page":"735","article-title":"Interaction of mercury compounds with muscarinic receptor subtypes in the rat brain","volume":"17","author":"Castoldi AF","year":"1996","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.35.040195.002135"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(99)00031-4"},{"key":"e_1_2_1_12_1","first-page":"719","article-title":"Effect of subchronic mercury exposure on electrocorticogram of rats","volume":"17","author":"D\u00e9si I","year":"1996","journal-title":"Neurotoxicology"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8760(93)90080-9"},{"key":"e_1_2_1_14_1","first-page":"381","article-title":"Effect of mercury compounds on acetylcholine transferase","volume":"30","author":"Dwivedi C","year":"1980","journal-title":"Res. 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