{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:17:52Z","timestamp":1767979072631,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T00:00:00Z","timestamp":1171411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nerve agents can be divided into G\u2010agents (sarin, soman, tabun, cyclosarin etc.) and V\u2010agents. The studies dealing with V\u2010agents (O\u2010alkyl S\u20102\u2010dialkylaminoethyl methyl phosphonothiolates) are limited to one or two representatives only (VX, Russian VX). Anticholinesterase properties of 11 V\u2010agents were studied in rats <jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p> Following intoxication with these agents in doses of 1 \u00d7 LD<jats:sub>50<\/jats:sub> (intramuscular administration), activities of cholinesterases in the blood were continuously monitored and half\u2010lives (<jats:italic>t<\/jats:italic><jats:sub>0.5<\/jats:sub>) of inhibition were determined. These values varied from 3 min (VX and some other agents) to 10\u201314 min (derivatives substituted on the phosphorus head by O\u2010ethyl\u2010 or O\u2010isopropyl\u2010, and by dimethyl\u2010, diethyl\u2010 and dibutyl\u2010 on the nitrogen). Acetylcholinesterase activities in selected parts of the brain and diaphragm (30 min after the intoxication) were also detected. A correlation between toxicities and rates of inhibition of the blood enzymes was demonstrated. A similar relationship between acetylcholinesterase inhibition <jats:italic>in vitro<\/jats:italic> (from literature data) and half\u2010lives of the blood cholinesterases was also observed. Though the chemical similarity of V compounds is evident, marked differences were observed among different derivatives; however, all agents examined had high inhibition potency corresponding to their toxicities. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1226","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T07:42:01Z","timestamp":1171438921000},"page":"458-463","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of blood cholinesterases following intoxication with VX and its derivatives"],"prefix":"10.1002","volume":"27","author":[{"given":"J.","family":"Bajgar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kuca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fusek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Karasova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kassa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Cabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Jun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Blaha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.04.031"},{"key":"e_1_2_1_3_1","first-page":"5","article-title":"Survey of chemicals for consideration as possible \u2018V\u2019 agents (in Czech)","volume":"9","author":"Bajgar J","year":"1968","journal-title":"Inf. Zpravodaj"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1972.tb08090.x"},{"key":"e_1_2_1_5_1","first-page":"3","article-title":"The influence of inhibitors and other factors on cholinesterases","volume":"34","author":"Bajgar J","year":"1991","journal-title":"Sbor. Ved. Pr. LFUK (Hradec Kralove)"},{"key":"e_1_2_1_6_1","first-page":"648","article-title":"Biological monitoring of exposure to nerve agents","volume":"49","author":"Bajgar J","year":"1992","journal-title":"Br. J. Ind. Med"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2423(04)38006-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1158"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2006.10.006"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420130020005"},{"key":"e_1_2_1_11_1","first-page":"25","volume-title":"Chemical Warfare Agents: Toxicity at Low Levels","author":"Benschop HP","year":"2001"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.11.003"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1081\/DCT-120005894"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2006.04.015"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(61)90145-9"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376520490429175"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1191\/096032799678845106"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00146-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810600846971"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376520590968770"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1053"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1084"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2006.pto_267.x"},{"key":"e_1_2_1_24_1","volume-title":"Chemical Warfare Agents. Toxicology and Treatment.","author":"Marrs TC","year":"1996"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1108"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1143"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.112.3.648"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.10.042"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480548809017884"},{"key":"e_1_2_1_30_1","first-page":"67","article-title":"Toxicities of O\u2010alkyl S\u2010(2\u2010dialkylaminoethyl) methyl phosphonothiolates (V\u2010compounds)","volume":"39","author":"Vachek J","year":"1996","journal-title":"Acta Med. (Hradec Kralove)"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066603258659"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-002-0375-1"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.1226","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.1226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:02:57Z","timestamp":1760544177000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.1226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,14]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1002\/jat.1226"],"URL":"https:\/\/doi.org\/10.1002\/jat.1226","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,14]]}}}