{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:08Z","timestamp":1761822968348,"version":"build-2065373602"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Organoselenocyanates represent an important class of chemopreventive agent, which possess antioxidative, antimutagenic as well as cancer chemopreventive properties. The present study is an attempt to evaluate the protective effect of diphenylmethyl selenocyanate \u2014 a synthetic organoselenocyanate against carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced hepatic damage in Swiss albino mice <jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p>Mice were pretreated with the Se\u2010compound orally in a duration dependent manner (7 and 15 days) to observe its protective action against an acute toxic dose (24 h) of CCl<jats:sub>4<\/jats:sub> (single injection at a dose of 20 \u00b5l and 50 \u00b5l kg<jats:sup>\u22121<\/jats:sup> b.w.) that induced hepatic necrosis and caused DNA damage (strand breaks) in the hepatocytes.<\/jats:p><jats:p>This study revealed that pretreatment with the Se\u2010compound reduced the extent of massive hepatic necrosis in a duration dependent manner, but it had no modulatory effect on hepatocellular apoptosis caused by acute toxic doses of CCl<jats:sub>4<\/jats:sub>. It was also found that the Se\u2010compound could significantly (<jats:italic>P<\/jats:italic> &lt; 0.01) prevent the CCl<jats:sub>4<\/jats:sub>\u2010induced elevation of DNA damage in hepatocytes measured by comet assay in a duration dependent manner.<\/jats:p><jats:p>So these findings will further strengthen the view that organoselenocyanate is an effective chemopreventive agent against acute hepatic damage, caused by halogenated alkanes such as CCl<jats:sub>4<\/jats:sub>. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1230","type":"journal-article","created":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T12:11:15Z","timestamp":1173442275000},"page":"527-537","source":"Crossref","is-referenced-by-count":14,"title":["Protective effect of diphenylmethyl selenocyanate against CCl<sub>4<\/sub>\u2010induced hepatic injury"],"prefix":"10.1002","volume":"27","author":[{"given":"Rajat Kumar","family":"Das","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sk. 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