{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:12:42Z","timestamp":1790885562775,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T00:00:00Z","timestamp":1176249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Resveratrol is a nonflavonoid polyphenol with antioxidant, anticancer and antiinflammatory properties. Moreover, it has been reported that this compound inhibits NF\u2010<jats:italic>\u03ba<\/jats:italic>B, which regulates the transcription of several genes including cytokines such as the profibrogenic TGF\u2010<jats:italic>\u03b2<\/jats:italic>. The aim of this work was to evaluate the pharmacological effects of resveratrol on CCl<jats:sub>4<\/jats:sub>\u2010induced cirrhosis in the rat. Four groups were formed: the control group that received the vehicles only; the CCl<jats:sub>4<\/jats:sub> group that received the toxin (0.4 g kg<jats:sup>\u22121<\/jats:sup>, i.p., three times a week, for 8 weeks); the CCl<jats:sub>4<\/jats:sub> plus resveratrol (10 mg kg<jats:sup>\u22121<\/jats:sup>, daily) group; and the resveratrol alone group. Alanine aminotransferase, alkaline phosphatase and bilirubins were increased by CCl<jats:sub>4<\/jats:sub>, but resveratrol afforded some degree of protection. Glycogen was decreased markedly by CCl<jats:sub>4<\/jats:sub> and resveratrol prevented almost completely this effect. No antioxidant effect of resveratrol was observed. One of the most prominent effects was on fibrosis which increased near 5\u2010fold (hydroxyproline) in the CCl<jats:sub>4<\/jats:sub> group; resveratrol preserved the content of collagen. These results were corroborated by histopathology. To elucidate the antifibrogenic mechanism of resveratrol, the activation of NF\u2010<jats:italic>\u03ba<\/jats:italic>B and the production of TGF\u2010<jats:italic>\u03b2<\/jats:italic> were measured; in both cases CCl<jats:sub>4<\/jats:sub> increased them and resveratrol abolished them; however, changes in NF\u2010<jats:italic>\u03ba<\/jats:italic>B were modest and did not reach statistical significance, while the increase in TGF\u2010<jats:italic>\u03b2<\/jats:italic> was about three fold and resveratrol decreased it under control values. Together, the present results indicate that resveratrol possesses a strong antifibrogenic effect at least in the CCl<jats:sub>4<\/jats:sub> model of cirrhosis. Moreover, the action mechanism is probably associated with its ability to reduce NF\u2010<jats:italic>\u03ba<\/jats:italic>B activation and TGF\u2010<jats:italic>\u03b2<\/jats:italic> content. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1249","type":"journal-article","created":{"date-parts":[[2007,4,11]],"date-time":"2007-04-11T09:27:10Z","timestamp":1176283630000},"page":"35-43","source":"Crossref","is-referenced-by-count":137,"title":["Resveratrol prevents fibrosis, NF\u2010<i>\u03ba<\/i>B activation and TGF\u2010<i>\u03b2<\/i> increases induced by chronic CCl<sub>4<\/sub> treatment in rats"],"prefix":"10.1002","volume":"28","author":[{"given":"Enrique","family":"Ch\u00e1vez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Reyes\u2010Gordillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Segovia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineko","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario G.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-9031-y"},{"key":"e_1_2_1_3_1","first-page":"2783","article-title":"Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies","volume":"24","author":"Aggarwal BB","year":"2004","journal-title":"Anticancer Res."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI24282"},{"key":"e_1_2_1_5_1","first-page":"269","volume-title":"Methods of Enzymatic Analysis","author":"Bergmeyer HU","year":"1983"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115821"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199704140-00035"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(02)00330-5"},{"key":"e_1_2_1_10_1","first-page":"192","article-title":"Isolation of intact nuclei for nuclear extract preparation from a fragile B lymphocyte cell line","volume":"19","author":"Dyer RB","year":"1995","journal-title":"Biotechniques"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92472-6"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00410-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306243282508"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1078\/0065-1281-00591"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.225"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/he.2000.5848"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.11.001"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00292.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.2741\/gressner"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80010-5"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90326-2"},{"key":"e_1_2_1_22_1","first-page":"557","article-title":"Resveratrol, a natural chemopreventive agent against degenerative diseases","volume":"53","author":"Ignatowicz E","year":"2001","journal-title":"Polish J. 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