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A number of toxicological parameters were evaluated in the testes of mice, such as <jats:italic>\u03b4\u2010<\/jats:italic>aminolevulinic acid dehydratase (<jats:italic>\u03b4\u2010<\/jats:italic>ALA\u2010D) activity, lipid peroxidation, ascorbic acid levels and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Ebselen attenuated lipid peroxidation levels altered by CdCl<jats:sub>2<\/jats:sub>. <jats:italic>\u03b4\u2010<\/jats:italic>ALA\u2010D activity inhibited by the highest dose of CdCl<jats:sub>2<\/jats:sub> was attenuated by ebselen. A significant negative correlation between lipid peroxidation levels and <jats:italic>\u03b4\u2010<\/jats:italic>ALA\u2010D activity was observed. Ebselen restored ascorbic acid levels reduced by CdCl<jats:sub>2<\/jats:sub>. A significant negative correlation between ascorbic acid levels and <jats:italic>\u03b4\u2010<\/jats:italic>ALA\u2010D activity reinforces the idea that ebselen attenuated the damage induced by CdCl<jats:sub>2<\/jats:sub> via its antioxidant property. The significant correlation between ALT and <jats:italic>\u03b4\u2010<\/jats:italic>ALA\u2010D activity supports the assumption that ebselen prevented damage caused by CdCl<jats:sub>2<\/jats:sub>. The results show that ebselen attenuated oxidative stress, a process important for CdCl<jats:sub>2<\/jats:sub> toxicity. 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