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In the first experiment, 8\u2010week\u2010old male rats treated with 6 or 9 mg kg<jats:sup>\u22121<\/jats:sup> NDP at a single intravenous dose were killed 2, 4, 7 and 14 days after dosing. In the second experiment, nonhydrated (Nhyd) or hydrated (Hyd) rats, treated with a single intravenous dose of 20 mg kg<jats:sup>\u22121<\/jats:sup> NDP, were killed 7 days after dosing. Besides renal function and histopathological examinations, the urinary excretion of platinum was measured. Histopathologically, NDP\u2010induced nephrotoxicity was initially characterized by single cell and\/or focal necrosis in the epithelium of distal tubules and collecting ducts as well as proximal tubules. In the later stage, subsequent cystic dilatation and regeneration occurred in these affected tubules, but incomplete tissue repair was still observed in the kidney 14 days after dosing. However, NDP\u2010induced nephrotoxicity was dramatically reduced by hydration, while it had no clear effects on myelotoxicity. Measurement of urinary platinum excretion revealed that the total amount of platinum excretion was significantly higher in Hyd\u2010NDP rats than that in Nhyd\u2010NDP rats. In terms of urinary concentration, Hyd\u2010NDP rats showed a lower concentration compared with that in Nhyd\u2010NDP rats. The current results suggest that NDP has the potential risk to cause nephrotoxicity at a human therapeutic dose without hydration and that pre\u2010 and post\u2010hydration at dosing can ameliorate this nephrotoxicity. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1292","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T12:19:29Z","timestamp":1186575569000},"page":"388-398","source":"Crossref","is-referenced-by-count":5,"title":["Time course of the change and amelioration of nedaplatin\u2010induced nephrotoxicity in rats"],"prefix":"10.1002","volume":"28","author":[{"given":"Takeki","family":"Uehara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aki","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikinori","family":"Torii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masuhisa","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoji","family":"Yamate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00685546"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2006.01.013"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0270-9295(03)00089-5"},{"key":"e_1_2_1_5_1","first-page":"351","article-title":"Avoidance of renal toxicity by 24\u2010hour infusion of cisplatin","volume":"65","author":"Bozzino JM","year":"1981","journal-title":"Cancer Treat. 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