{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:13:06Z","timestamp":1791094386280,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T00:00:00Z","timestamp":1191974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Allergic contact dermatitis is the serious unwanted effect arising from the use of consumer products such as cosmetics. Isoeugenol is a fragrance chemical with spicy, carnation\u2010like scent, is used in many kinds of cosmetics and is a well\u2010known moderate human sensitizer. It was previously reported that the dimerization of eugenol yielded two types of dimer possessing different sensitization potencies. This study reports the differences in skin sensitization potencies for isoeugenol and two types of dimer, <jats:italic>\u03b2<\/jats:italic>\u2010O\u20104\u2010dilignol and dehydrodiisoeugenol (DIEG), as evaluated by the non\u2010radioisotopic local lymph node assay (non\u2010RI LLNA) and guinea pig maximization test. In the guinea pig maximization test, isoeugenol, <jats:italic>\u03b2<\/jats:italic>\u2010O\u20104\u2010dilignol and DIEG were classified as extreme, weak and moderate sensitizers, respectively. As for the results of non\u2010RI LLNA, the EC3 for isoeugenol, <jats:italic>\u03b2<\/jats:italic>\u2010O\u20104\u2010dilignol and DIEG were calculated as 12.7%, &gt;30% and 9.4%, respectively. The two types of isoeugenol dimer showed different sensitizing activities similar to the case for eugenol dimers. A reduction of sensitization potency achieved by dimerization may lead to developing safer cosmetic ingredients. Isoeugenol dimers are not currently used for fragrance chemicals. However, the dimerization of isoeugenol may yield a promising candidate as a cosmetic ingredient with low sensitization risk. The data may also provide useful information for the structure\u2010activity relationship (SAR) in skin sensitization. Copyright \u00a9 2007 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1305","type":"journal-article","created":{"date-parts":[[2007,10,10]],"date-time":"2007-10-10T12:18:42Z","timestamp":1192018722000},"page":"530-534","source":"Crossref","is-referenced-by-count":13,"title":["Skin sensitization potency of isoeugenol and its dimers evaluated by a non\u2010radioisotopic modification of the local lymph node assay and guinea pig maximization test"],"prefix":"10.1002","volume":"28","author":[{"given":"Masahiro","family":"Takeyoshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,10,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb05217.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00490.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2000.042006344.x"},{"key":"e_1_2_1_5_1","volume-title":"Computational Handbook of Statistics","author":"Bruning JL","year":"1997"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(199609)16:5<459::AID-JAT366>3.0.CO;2-H"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1969.42"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05633.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00302.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1045"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.951"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(00)00315-5"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1248\/yakushi1947.118.8_324"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1248\/yakushi1947.120.11_1221","article-title":"Analysis of contact dermatitis by cytokines IV, skin sensitization of biphenyl compounds","volume":"120","author":"Yamazaki S","year":"2000","journal-title":"Yakugaku Zassi"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.1305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.1305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:27:12Z","timestamp":1760542032000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.1305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1002\/jat.1305"],"URL":"https:\/\/doi.org\/10.1002\/jat.1305","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,10]]}}}