{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:50:23Z","timestamp":1760575823487,"version":"build-2065373602"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The agricultural fungicide <jats:italic>N<\/jats:italic>\u2010(3,5\u2010dichlorophenyl)succinimide (NDPS) is a more potent nephrotoxicant in female rats than in males. Similarly, nephrotoxicant NDPS metabolites studied to date in male and female rats have also demonstrated gender differences, being twice as potent as nephrotoxicants in females as in males. The purpose of this study was to examine the nephrotoxic potential of <jats:italic>N<\/jats:italic>\u2010(3,5\u2010dichlorophenyl)\u20103\u2010hydroxysuccinimide (3\u2010NDHSA) in male and female Fisher 344 rats to determine if gender differences in nephrotoxic potential also exist for this metabolite. Rats (four per group) were administered a single intraperitoneal (i.p.) injection of 3\u2010NDHSA (0.1, 0.2 or 0.4\u00a0\u2009mmol\u00a0kg<jats:sup>\u22121<\/jats:sup>) or vehicle, and renal function was monitored at 24 and 48\u00a0h. 3\u2010NDHSA 0.1\u00a0mmol\u00a0kg<jats:sup>\u22121<\/jats:sup> did not induce nephrotoxicity in male or female rats. In male rats, 3\u2010NDHSA 0.2\u00a0mmol\u00a0kg<jats:sup>\u22121<\/jats:sup> induced mild nephrotoxicity seen as diuresis and transient, mild proteinuria. However, 3\u2010NDHSA 0.4\u00a0mmol\u00a0kg<jats:sup>\u22121<\/jats:sup> induced marked nephrotoxicity. In female rats, 3\u2010NDHSA 0.2\u00a0mmol\u00a0kg<jats:sup>\u22121<\/jats:sup> induced mild nephrotoxicity, as evidenced by transient diuresis and proteinuria. As in males, 3\u2010NDHSA 0.4\u00a0mmol\u00a0kg<jats:sup>\u22121<\/jats:sup> induced marked nephrotoxicity. These results indicate that, unlike NDPS and other nephrotoxic NDPS metabolites, 3\u2010NDHSA does not exhibit gender differences in nephrotoxic potential. In addition, in comparison with NDPS and other nephrotoxic NDPS metabolites, 3\u2010NDHSA is a less potent nephrotoxicant that NDHS or 2\u2010NDHSA and similar to NDPS in nephrotoxic potential in male rats. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1350","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T12:18:03Z","timestamp":1208348283000},"page":"867-873","source":"Crossref","is-referenced-by-count":2,"title":["Nephrotoxicity induced by <i>N<\/i>\u2010(3,5\u2010dichlorophenyl)\u20103\u2010hydroxysuccinamic acid in male and female Fischer 344 rats"],"prefix":"10.1002","volume":"28","author":[{"given":"Gary O.","family":"Rankin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suk\u2010kil","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne K.","family":"Anestis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(91)90107-I"},{"key":"e_1_2_1_3_1","first-page":"425","article-title":"Experimental interstitial renal fibrosis in rats: nephritis induced by N\u2010(3,5\u2010dichlorophenyl)succinimide","volume":"64","author":"Barrett MC","year":"1983","journal-title":"Br. 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