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Cd administration in the form of CdCl<jats:sub>2 <\/jats:sub>(at a dose of 4\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> body weight for 3 days, orally) increased the intracellular accumulation of metallic Cd, reactive oxygen species and super oxide radicals. The toxin also augmented the extent of lipid peroxidation, protein carbonylation and the levels of glutathione disulfide. Activities of the antioxidant enzymes and the levels of reduced glutathione as well as total thiols have been significantly decreased due to Cd exposure. In addition, the toxin also caused significant DNA degradation (as evidenced from DNA smearing and diphenylamine reaction). Oral administration of taurine (at a dose of 100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> body weight for 5 days) was found to be very effective in the prevention of Cd\u2010induced oxidative impairment in the brain tissue of experimental mice. In addition, taurine treatment could also prevent the reduction in the <jats:italic>in vivo<\/jats:italic> antioxidant power linearly up to a dose of 100\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> body weight. The preventive role of taurine against Cd\u2010induced cerebral oxidative damage was supported by the observation under scanning electron microscope as well as histological examination of brain segments. To validate the experimental results, a well\u2010known water soluble antioxidant, vitamin C, was used as the positive control in the study. In all, the results suggest that taurine plays a beneficial role against Cd\u2010induced cerebral oxidative stress. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1363","type":"journal-article","created":{"date-parts":[[2008,6,12]],"date-time":"2008-06-12T07:48:31Z","timestamp":1213256911000},"page":"974-986","source":"Crossref","is-referenced-by-count":45,"title":["Cadmium\u2010induced neurological disorders: prophylactic role of taurine"],"prefix":"10.1002","volume":"28","author":[{"given":"Mahua","family":"Sinha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasenjit","family":"Manna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parames C.","family":"Sil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,6,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/bmme.1995.1005"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-006-3384-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2560251"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(01)00229-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)99005-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(72)90080-X"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007604414773"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2056"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00245-7"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(92)90179-I"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)34096-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850260310"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90090-6"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(90)86134-H"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327104ht432oa"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3949.989"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.11003"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(67)90037-4"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(02)00546-2"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3436-5_38"},{"key":"e_1_2_1_24_1","first-page":"183","article-title":"Influence of vitamin C on cadmium absorption and distribution in rats","volume":"18","author":"Grosicki A.","year":"2004","journal-title":"Toxicology"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1987.tb01508.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1263(1998090)18:5<317::AID-JAT514>3.0.CO;2-U"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(98)00126-7"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)42083-8"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(85)90010-4"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)81456-4"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90326-2"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0095-4543(05)70185-8"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.1.101"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(01)00472-3"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(92)90122-N"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01919148"},{"key":"e_1_2_1_37_1","first-page":"130","article-title":"A modified spectrophotometric assay of superoxide dismutase","volume":"21","author":"Kakkar P","year":"1984","journal-title":"Ind. 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