{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T14:15:21Z","timestamp":1768486521275,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T00:00:00Z","timestamp":1215993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Liver fibrosis is characterized by an excess of collagen fiber deposition, and it is known that Kupffer cells play an important role by immunomodulation of the toxic response. Methyl palmitate (MP) is an effective Kupffer cell inhibitor. The aim of this work was to evaluate the effect of MP on experimental liver fibrosis. Four groups were formed: the control group, which received the vehicles only; CCl<jats:sub>4<\/jats:sub> group (0.4\u00a0g\u00a0kg<jats:sup>\u22121<\/jats:sup>, i.p., three times a week, for eight weeks); CCl<jats:sub>4<\/jats:sub> plus MP (300\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>, i.p., daily); and MP alone. Alanine aminotransferase was increased by CCl<jats:sub>4<\/jats:sub>, and MP did not prevent this increase. Lipid peroxidation was increased markedly by CCl<jats:sub>4<\/jats:sub>; again, MP was not able to prevent this effect. Fibrosis increased nearly 6\u2010fold (measured as liver hydroxyproline content) in the CCl<jats:sub>4<\/jats:sub> group; MP preserved the normal content of collagen. These results were corroborated by histopathology. To elucidate the antifibrogenic mechanism of MP, we measured the production of TGF\u2010<jats:italic>\u03b2<\/jats:italic>; CCl<jats:sub>4<\/jats:sub> increased this cytokine several\u2010fold, and MP abolished this increase. Collectively the present results indicate that MP possesses a strong antifibrogenic effect at least in the CCl<jats:sub>4<\/jats:sub> model of fibrosis. The antifibrotic effect of MP is probably associated with its ability to reduce TGF\u2010<jats:italic>\u03b2<\/jats:italic> content, maybe by immunomodulation of Kupffer cells functioning. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1368","type":"journal-article","created":{"date-parts":[[2008,7,14]],"date-time":"2008-07-14T09:33:03Z","timestamp":1216027983000},"page":"1021-1026","source":"Crossref","is-referenced-by-count":17,"title":["Methyl palmitate prevents CCl<sub>4<\/sub>\u2010induced liver fibrosis"],"prefix":"10.1002","volume":"28","author":[{"given":"Adriana","family":"Rodr\u00edguez\u2010Rivera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Galicia\u2010Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Reyes\u2010Gordillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Segovia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario G.","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineko","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(99)00118-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524282"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.02.001"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10590"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00116.2002"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2660141"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21802"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2006.03.002"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1078\/0065-1281-00591"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1993.1061"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.12.6244"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.1991.tb01983.x"},{"key":"e_1_2_1_15_1","first-page":"34","article-title":"The role of Kupffer cells in the development of hepatic dysfunction during sepsis","volume":"105","author":"Meng X","year":"1992","journal-title":"Chin. 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