{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T01:00:10Z","timestamp":1784768410665,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T00:00:00Z","timestamp":1216857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We previously reported a 65\u2010year\u2010old man who aspirated an alkaline detergent containing 3.3% w\/v (weight of solute per volume of solution) monoethanolamine (MEA) into his lungs, causing asthma\u2010like symptoms. We presently describe the mechanism of MEA\u2010induced bronchoconstriction according to findings in guinea pigs. In anesthetized, artificially ventilated animals, changes in airway opening pressure (<jats:italic>P<\/jats:italic><jats:sub>ao<\/jats:sub>) were measured as an index of bronchoconstriction. An aerosol of 3.3% MEA solution (0.1\u00a0ml\u00a0kg<jats:sup>\u22121<\/jats:sup>) inhaled through a tracheal cannula induced significantly stronger bronchoconstriction than an aerosol of potassium hydroxide (KOH) solution (0.1\u00a0ml\u00a0kg<jats:sup>\u22121<\/jats:sup>) at the same pH. MEA\u2010induced bronchoconstriction was significantly suppressed by premedication with intravenously injected atropine sulfate (3\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>), a muscarinic receptor antagonist, or diphenhydramine hydrochloride (10\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>), a histamine\u2010H<jats:sub>1<\/jats:sub> receptor antagonist. MEA\u2010induced bronchoconstriction was not enhanced by premedication with an intravenous injection of neostigmine (0.1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>), an acetylcholinesterase inhibitor. When bronchoconstriction was induced by MEA, histamine concentrations in bronchoalveolar lavage fluid (BALF) were not significantly greater than in BALF after KOH\u2010induced bronchoconstriction or in BALF after inhalation of physiologic saline. <jats:italic>In vitro<\/jats:italic>, contraction of trachea denuded of epithelium during superfusion with MEA (10\u00a0m<jats:sc>m<\/jats:sc>) was suppressed by premedication with pyrilamine maleate, a histamine\u2010H<jats:sub>1<\/jats:sub> receptor antagonist, at 10 and 100\u00a0\u00b5<jats:sc>m<\/jats:sc>. Contraction of trachea denuded of epithelium during superfusion with MEA (10\u00a0m<jats:sc>m<\/jats:sc>) was suppressed by premedication with atropine sulfate at 10 and 100\u00a0\u00b5<jats:sc>m<\/jats:sc>. These results suggest that asthma\u2010like symptoms may result partly from agonistic MEA effects at histamine\u2010H<jats:sub>1<\/jats:sub> receptors and muscarinic receptors. Copyright \u00a9 2008 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1373","type":"journal-article","created":{"date-parts":[[2008,7,24]],"date-time":"2008-07-24T04:52:20Z","timestamp":1216875140000},"page":"15-19","source":"Crossref","is-referenced-by-count":11,"title":["Effects of inhaled monoethanolamine on bronchoconstriction"],"prefix":"10.1002","volume":"29","author":[{"given":"Y.","family":"Kamijo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ide","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Soma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Majima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,24]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"374","article-title":"Respiratory allergy due to chemical compounds encountered in the rubber, lacquer, shellac, and beauty culture industries","volume":"34","author":"Gelfand HH.","year":"1963","journal-title":"J. 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