{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:34:47Z","timestamp":1760574887953,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T00:00:00Z","timestamp":1277769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to evaluate immunomodulatory and hepatoprotective effects of glycoprotein isolated from <jats:italic>Morus indica<\/jats:italic> Linne (MIL glycoprotein) on carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced liver injury. In the present study, MIL glycoprotein (5 and 10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> body weight) was administered to ICR mice for 7 days prior to CCl<jats:sub>4<\/jats:sub> treatment. We evaluated the activities of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and thiobarbituric acid\u2010reactive substances (TBARS), and expression of inflammation\u2010related mediators including cyclooxygenase (COX)\u20102, tumor necrosis factor (TNF)\u2010<jats:italic>\u03b1<\/jats:italic>, and interleukin (IL)\u20101<jats:italic>\u03b2<\/jats:italic> in CCl<jats:sub>4<\/jats:sub>\u2010treated mice. Our results revealed that MIL glycoprotein reduced the activities of ALT, LDH and TBARS in serum from CCl<jats:sub>4<\/jats:sub>\u2010treated mice. We also found that MIL glycoprotein reduced the activity of COX\u20102 and expression of TNF\u2010<jats:italic>\u03b1<\/jats:italic> and IL\u20101<jats:italic>\u03b2<\/jats:italic> in liver from CCl<jats:sub>4<\/jats:sub>\u2010treated mice. Moreover, administration of MIL glycoprotein suppressed on stress\u2010activated protein kinase\/c\u2010jun N\u2010terminal kinase phosphorylation and activator protein\u20101 transcriptional activation in livers from CCl<jats:sub>4<\/jats:sub>\u2010treated mice. The results from these experiments indicate that MIL glycoprotein effectively protects against liver injury, mainly through downregulation of oxidative stress and the inflammatory response. In conclusion, we suggest that the MIL glycoprotein might be one component of health supplements for prevention of liver diseases. Copyright \u00a9 2010 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1557","type":"journal-article","created":{"date-parts":[[2010,6,29]],"date-time":"2010-06-29T05:37:58Z","timestamp":1277789878000},"page":"754-760","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory effect of MIL glycoprotein on expression of pro\u2010inflammatory mediators in carbon tetrachloride\u2010induced mice liver damage"],"prefix":"10.1002","volume":"30","author":[{"given":"Phil\u2010Sun","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kye\u2010Taek","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(03)00322-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.2.401"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00157-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50010-4"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-091302-2.50049-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043456098"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(78)52032-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.338"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)32099-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.05.031"},{"key":"e_1_2_6_12_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0026-895X(25)10824-9","article-title":"Reaction of glutathione with a free radical metabolite of carbon tetrachloride","volume":"37","author":"Connor HD","year":"1990","journal-title":"Mol. 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