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Mice received one daily dose of HgCl<jats:sub>2<\/jats:sub> (4.6\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, subcutaneously) for three consecutive days. Thirty minutes after the last injection of HgCl<jats:sub>2<\/jats:sub>, mice received a single dose of (PhSe)<jats:sub>2<\/jats:sub> (31.2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, subcutaneously). Five hours after (PhSe)<jats:sub>2<\/jats:sub> administration, mice were euthanized and <jats:italic>\u03b4<\/jats:italic>\u2010aminolevulinate dehydratase, catalase (CAT), glutathione <jats:italic>S<\/jats:italic>\u2010transferase (GST) and Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup>\u2010ATPase activities as well as thiobarbituric acid\u2010reactive substances (TBARS), ascorbic acid and mercury levels were determined in kidney and liver. Parameters in plasma (urea, creatinine, protein and erythropoietin), whole blood (hematocrit and hemoglobin) and urine (protein) were also investigated. HgCl<jats:sub>2<\/jats:sub> + (PhSe)<jats:sub>2<\/jats:sub> exposure caused a decrease in renal GST and Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup>\u2010ATPase activities and an increase in renal ascorbic acid and TBARS concentrations when compared with the HgCl<jats:sub>2<\/jats:sub> group. (PhSe)<jats:sub>2<\/jats:sub> potentiated the increase in plasma urea caused by HgCl<jats:sub>2<\/jats:sub>. HgCl<jats:sub>2<\/jats:sub> + (PhSe)<jats:sub>2<\/jats:sub> exposure caused a reduction in plasma protein levels and an increase in hemoglobin and hematocrit contents when compared with the HgCl<jats:sub>2<\/jats:sub> group. There was a significant reduction in hepatic CAT activity and an increase in TBARS levels in mice exposed to HgCl<jats:sub>2<\/jats:sub> + (PhSe)<jats:sub>2<\/jats:sub> when compared with the HgCl<jats:sub>2<\/jats:sub> group. The results demonstrated that (PhSe)<jats:sub>2<\/jats:sub> did not modify mercury levels in mice. In conclusion, (PhSe)<jats:sub>2<\/jats:sub> potentiated damage caused by HgCl<jats:sub>2<\/jats:sub> affecting mainly the renal tissue. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1631","type":"journal-article","created":{"date-parts":[[2011,1,31]],"date-time":"2011-01-31T09:15:32Z","timestamp":1296465332000},"page":"773-782","source":"Crossref","is-referenced-by-count":11,"title":["Diphenyl diselenide potentiates nephrotoxicity induced by mercuric chloride in mice"],"prefix":"10.1002","volume":"31","author":[{"given":"Ricardo","family":"Brand\u00e3o","sequence":"first","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Centro de Ci\u00eancias da Sa\u00fade Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael N.","family":"Moresco","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Centro de Ci\u00eancias da Sa\u00fade Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luziane P.","family":"Bell\u00e9","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Centro de Ci\u00eancias da Sa\u00fade Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon R.","family":"Leite","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara L.","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adalto","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas Universidade Federal do Rio Grande\u2010FURG  CEP 96201\u2010900 Rio Grande RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina W.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Centro de Ci\u00eancias Naturais e Exatas Universidade Federal de Santa Maria  CEP 97105\u2010900 Santa Maria RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,1,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.45.388"},{"key":"e_1_2_6_4_1","first-page":"830","article-title":"Mercury blocks Na+\u2010K+\u2010ATPase by a ligand\u2010dependent and reversible mechanism","volume":"262","author":"Anner BM","year":"1992","journal-title":"Am. 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