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The association of COX and liver injury has been, in part, due to the presence of COX\u20102 isoform in damaged liver and the possible induction of this enzyme by profibrotic molecules like Transforming Growth Factor\u2010<jats:italic>\u03b2<\/jats:italic> (TGF\u2010<jats:italic>\u03b2<\/jats:italic>). The aim of this work was to evaluate the effects of two of the most used NSAIDs, acetyl salicylic acid (ASA) and ibuprofen (IBP), on experimental liver fibrosis. We formed experimental groups of rats including vehicle and drug controls, damage induced by chronic CCl<jats:sub>4<\/jats:sub> (0.4\u2009g kg<jats:sup>\u22121<\/jats:sup>, i.p., three times per week, for 8\u2009weeks) administration, and CCl<jats:sub>4<\/jats:sub> plus ASA (100\u2009mg kg<jats:sup>\u22121<\/jats:sup>, p.o., daily) or IBP (30\u2009mg kg<jats:sup>\u22121<\/jats:sup>, p.o., daily). Both drugs showed important antifibrotic properties. They inhibited COX\u20102 activity, prevented oxidative stress measured as lipid peroxidation and glutathione content, and ASA inhibited partially and IBP totally increased TGF\u2010<jats:italic>\u03b2<\/jats:italic> expression and collagen content. ASA and IBP prevented translocation of NF<jats:italic>\u03ba<\/jats:italic>B to the nucleus and, interestingly, ASA induced MMP\u20102 and MMP\u201013 whereas IBP induced MMP\u20102, MMP\u20109 and MMP\u201013. As a whole, these effects explain the beneficial effects of ASA and IBP on experimental liver fibrosis. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1638","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T10:44:01Z","timestamp":1306147441000},"page":"51-59","source":"Crossref","is-referenced-by-count":24,"title":["Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl<sub>4<\/sub>"],"prefix":"10.1002","volume":"32","author":[{"given":"Enrique","family":"Ch\u00e1vez","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Castro\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineko","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Departamento de Infect\u00f3mica y Patog\u00e9nesis Molecular Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"P\u00e9rez Salazar","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular Cinvestav\u2010IPN  Apdo Postal 14\u2010740 M\u00e9xico 07000 D. F. 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