{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:11:34Z","timestamp":1790046694740,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T00:00:00Z","timestamp":1304035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Acrylamide (AA), a neurotoxic, testicular toxic, genotoxic and carcinogenic chemical, has been reported to be formed in processed food, and sensitivity to AA intoxication in childhood is a concern. In the present study, to clarify the general toxicological profile of AA in juvenile rats, subchronic toxicity was evaluated in F344 rats administered AA in the drinking water at 0 (control), 10, 20 and 40\u2009ppm, presented to the dams (three per group) immediately after the birth of their litters, through lactation (3\u2009weeks), and directly to the offspring in their drinking water after weaning for a further 9\u2009weeks (12\u2009weeks total). Treatment with AA caused a decrease in body weights in 20 and 40\u2009ppm F<jats:sub>1<\/jats:sub> females, compared with the controls. Average AA intake throughout the treatment period for the 10, 20 and 40\u2009ppm groups after weaning was equivalent to 1.0, 2.1 and 4.4\u2009mg kg<jats:sup>\u22121<\/jats:sup> body weight per day, respectively, in males and 1.2, 2.5 and 4.9\u2009mg kg<jats:sup>\u22121<\/jats:sup> body weight per day, respectively, in females. No toxicologically significant organ weight changes were observed. AA\u2010induced histopathological changes were limited to focal degeneration and necrosis of the seminiferous epithelium in the testes and desquamated epithelium in the ducts of epididymides, noted only in 40\u2009ppm males. Taken together with previous reports, juvenile rats are not necessarily more susceptible to AA\u2010induced toxicity as compared with young adults. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1686","type":"journal-article","created":{"date-parts":[[2011,4,29]],"date-time":"2011-04-29T00:58:27Z","timestamp":1304038707000},"page":"959-967","source":"Crossref","is-referenced-by-count":7,"title":["Juvenile rats do not exhibit elevated sensitivity to acrylamide toxicity after oral administration for 12\u2009weeks"],"prefix":"10.1002","volume":"32","author":[{"given":"Shigeaki","family":"Takami","sequence":"first","affiliation":[{"name":"Division of Pathology National Institute of Health Sciences  1\u201018\u20101 Kamiyoga, Setagaya\u2010ku Tokyo 158\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Imai","sequence":"additional","affiliation":[{"name":"Division of Pathology National Institute of Health Sciences  1\u201018\u20101 Kamiyoga, Setagaya\u2010ku Tokyo 158\u20108501 Japan"},{"name":"Central Animal Laboratory National Cancer Center Research Institute  5\u20101\u20101 Tsukiji, Chuo\u2010ku Tokyo 104\u20100045 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Man","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pathology National Institute of Health Sciences  1\u201018\u20101 Kamiyoga, Setagaya\u2010ku Tokyo 158\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Division of Pathology National Institute of Health Sciences  1\u201018\u20101 Kamiyoga, Setagaya\u2010ku Tokyo 158\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Hirose","sequence":"additional","affiliation":[{"name":"Division of Pathology National Institute of Health Sciences  1\u201018\u20101 Kamiyoga, Setagaya\u2010ku Tokyo 158\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Division of Pathology National Institute of Health Sciences  1\u201018\u20101 Kamiyoga, Setagaya\u2010ku Tokyo 158\u20108501 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,4,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx960113p"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.02.028"},{"key":"e_1_2_6_4_1","first-page":"107","article-title":"Carcinogenic effects of acrylamide in Sencar and A\/J mice","volume":"44","author":"Bull RJ","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304\u20103835(84)90138\u20101"},{"key":"e_1_2_6_6_1","first-page":"157","article-title":"Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144\u2009days of recovery","volume":"4","author":"Burek JD","year":"1980","journal-title":"J. Environ. Pathol. Toxicol."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.11.004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1995.1112"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890\u20106238(99)00043\u2010X"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.03.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5572.134"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800277h"},{"key":"e_1_2_6_13_1","unstructured":"IARC.1994.Acrylamide. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Some Industrial Chemicals Vol. 60. International Agency for Research on Cancer: Lyon;389\u2013433."},{"key":"e_1_2_6_14_1","unstructured":"JECFA.2005. Summary and conclusions.Sixty\u2010fourth Meeting Rome 8\u201317 February 2005. Available from:http:\/\/www.who.int\/ipcs\/food\/jecfa\/summaries\/summary_report_64_final.pdf(accessed 23 August 2010)."},{"key":"e_1_2_6_15_1","unstructured":"JECFA.2010. Summary and conclusions.Seventy\u2010second Meeting Rome 16\u201325 February 2010. Available from:http:\/\/www.who.int\/foodsafety\/chem\/summary72_rev.pdf(accessed 23 August 2010)."},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041\u2010008X(86)90109\u20102"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278\u20106915(03)00187\u2010X"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.07.008"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041\u2010008X(02)00072\u20108"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2004.10.012"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383\u20105718(02)00281\u20104"},{"key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0317167100019739","article-title":"A review of acrylamide neurotoxicity. Part I. Properties, uses and human exposure","volume":"1","author":"Spencer PS","year":"1974","journal-title":"Can. J. Neurol. Sci."},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1289\/ehp.7511129","article-title":"Nervous system degeneration produced by acrylamide monomer","volume":"11","author":"Spencer PS","year":"1975","journal-title":"Environ. Health Perspect."},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.11"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010009\u20100418\u2010y"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.02.023"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf020302f"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890\u20106238(00)00097\u20106"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0890\u20106238(00)00066\u20106"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892\u20100362(94)00071\u2010K"},{"key":"e_1_2_6_31_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.4142\/jvs.2005.6.2.103","article-title":"Genotoxicity and toxicological effects of acrylamide on reproductive system in male rats","volume":"6","author":"Yang HJ","year":"2005","journal-title":"J. Vet. Sci."}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.1686","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.1686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:07:08Z","timestamp":1760522828000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.1686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,29]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1002\/jat.1686"],"URL":"https:\/\/doi.org\/10.1002\/jat.1686","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,29]]}}}