{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:34:01Z","timestamp":1760574841063,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T00:00:00Z","timestamp":1315526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. In order to improve the treatment of osteoporosis, identification of anabolic agents with minimal side effects is highly desirable. <jats:italic>Cimicifuga racemosa<\/jats:italic> has a long and diverse history of medicinal use and deoxyactein isolated from this species is one of the major constituents. In the present study, the effect of deoxyactein on the function of osteoblastic MC3T3\u2010E1 cells was studied. Deoxyactein caused a significant elevation of cell growth, alkaline phosphatase activity, collagen content, and mineralization in the cells (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, deoxyactein significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) decreased the production of reactive oxygen species (ROS) and osteoclast differentiation\u2010inducing factors such as TNF\u2010<jats:italic>\u03b1<\/jats:italic>, IL\u20106 and receptor activator of nuclear factor\u2010<jats:italic>\u03ba<\/jats:italic>B ligand in the presence of antimycin A, which inhibits mitochondrial electron transport and has been used as an ROS generator. These results demonstrate that deoxyactein may have positive effects on skeletal structure. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1733","type":"journal-article","created":{"date-parts":[[2011,9,9]],"date-time":"2011-09-09T15:45:47Z","timestamp":1315583147000},"page":"190-195","source":"Crossref","is-referenced-by-count":18,"title":["Deoxyactein stimulates osteoblast function and inhibits bone\u2010resorbing mediators in MC3T3\u2010E1 cells"],"prefix":"10.1002","volume":"33","author":[{"given":"Eun Mi","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Food and Nutrition, Education Graduate School Kyung Hee University  1, Hoegi\u2010dong, Dongdaemun\u2010gu Seoul 130\u2010701 Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,9,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-6009(91)90100-E"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.04.031"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.04.037"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1991.00400100100017"},{"key":"e_1_2_7_8_1","first-page":"419","volume-title":"Osteoporosis","author":"Cooper C","year":"1996"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2008.11.005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1997.tb00442.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2005.05.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(98)00077-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21508"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960862"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00695-8"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.2.115"},{"key":"e_1_2_7_18_1","first-page":"93","article-title":"Black cohosh: efficacy, safety, and use in clinical and preclinical applications","volume":"7","author":"McKenna DJ","year":"2001","journal-title":"Altern. 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