{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:29:32Z","timestamp":1787509772157,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,11,26]],"date-time":"2011-11-26T00:00:00Z","timestamp":1322265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The zebrafish model has been developed and evaluated for its ability to predict the toxicity of chemicals. Zebrafish additionally serve as an excellent model for assessing drug\u2010induced cardiotoxicity, although zebrafish and mammalian hearts differ in structure. Recently, regulatory authorities have expressed concerns about a possible relationship between antipsychotics and risk of QTc interval prolongation, serious arrhythmia and sudden cardiac death. In the current study, we performed a cardiovascular risk assessment of six atypical antipsychotic drugs in zebrafish, specifically, aripiprazole, clozapine, olanzapine, quetiapine, risperidone and ziprasidone. Visual endpoints, such as lethality, edema (the presence of heart and trunk edema), hemorrhage (clustering of a pool of blood in an area outside the normal circulation), abnormal body shape (including bent or misshapen caudal region of the larvae) and motility, were evaluated as general toxicity endpoints, and the heart beat rate calculated as the cardiovascular toxicity endpoint. The zebrafish model facilitates determination of the heart beat rate, and may thus be an attractive screening tool for cardiovascular risk assessment of atypical antipsychotic drugs to understand the variations in response to QT\u2010prolonging drugs. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1768","type":"journal-article","created":{"date-parts":[[2011,11,26]],"date-time":"2011-11-26T00:39:59Z","timestamp":1322267999000},"page":"466-470","source":"Crossref","is-referenced-by-count":35,"title":["Cardiovascular risk assessment of atypical antipsychotic drugs in a zebrafish model"],"prefix":"10.1002","volume":"33","author":[{"given":"Sung Hak","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Animal Science and Biotechnology Chungnam National University  Yuseong\u2010gu, Gung\u2010dong 220 Daejeon 305\u2010764 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Rye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology Chungnam National University  Yuseong\u2010gu, Gung\u2010dong 220 Daejeon 305\u2010764 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong Xun","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology Chungnam National University  Yuseong\u2010gu, Gung\u2010dong 220 Daejeon 305\u2010764 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza K.","family":"Oqani","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology Chungnam National University  Yuseong\u2010gu, Gung\u2010dong 220 Daejeon 305\u2010764 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Il","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Biotechnology Chungnam National University  Yuseong\u2010gu, Gung\u2010dong 220 Daejeon 305\u2010764 Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1192\/apt.12.1.35"},{"key":"e_1_2_6_3_1","first-page":"71","article-title":"Evaluation of the toxic effects of clozapine in zebrafish (Danio rerio) embryos with the fish embryo toxicity test","volume":"1","author":"Akande MG","year":"2010","journal-title":"Int. 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