{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:52:03Z","timestamp":1789887123424,"version":"4.0.1"},"reference-count":136,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:00:00Z","timestamp":1326153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The stratum corneum's (SC) functions include protection from external hazardous environments, prevention of water loss and regulation of body temperature. While intact skin absorption studies are abundant, studies on compromised skin permeability are less common, although products are often used to treat affected skin. We reviewed literature on percutaneous absorption through abnormal skin models. Tape stripping is used to disrupt water barrier function. Studies demonstrated that physicochemical properties influence the stripping effect: water\u2010soluble drugs are more affected. Abrasion did not affect absorption as much. Freezing is commonly used to preserve skin. It does not seem to modify water absorption, but still increases the penetration of compounds. Comparatively, heating the skin consistently increased percutaneous absorption. Removing SC lipids may increase percutaneous absorption of drugs. Many organic solvents are employed to delipidize. Delipidization with chloroform\u2013methanol increased hydrophilic compound permeability, but not lipophilic. Acetone pre\u2010treatment enhanced hydrophilic compound penetration. More data is needed to determine influence on highly lipophilic compound penetration. Sodium lauryl sulfate (SLS) induces irritant dermatitis and is frequently used as a model. Studies revealed that SLS increases hydrophilic compound absorption, but not lipophilic. However, skin irritation with other chemicals increases lipophilic penetration as much as hydrophilic. Animal studies show that UV exposure increases percutaneous absorption whereas human studies do not. Human studies show increased penetration in psoriatic and atopic dermatitis skin. The data summarized here begin to characterize flux alteration associated with damaged skin. Understanding the degree of alteration requires interpretation of involved conditions and the enlarging of our database to a more complete physicochemical spectrum. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/jat.1773","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T04:07:28Z","timestamp":1326168448000},"page":"537-563","source":"Crossref","is-referenced-by-count":68,"title":["Percutaneous absorption in diseased skin: an overview"],"prefix":"10.1002","volume":"32","author":[{"given":"Audris","family":"Chiang","sequence":"first","affiliation":[{"name":"University of California Medical School  San Francisco CA 94143\u20100989 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Tudela","sequence":"additional","affiliation":[{"name":"University of California Medical School  San Francisco CA 94143\u20100989 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard I.","family":"Maibach","sequence":"additional","affiliation":[{"name":"University of California Medical School  San Francisco CA 94143\u20100989 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90288-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1993.tb00258.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1995.tb02668.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12366068"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2007.06.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1996.tb05933.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195\u20106701(85)80061\u2010X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12531096"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(81)90125-X"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600710222"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"In vivo microdialysis for the investigation of drug levels in the dermis and the effect of barrier perturbation on cutaneous drug penetration: studies in hairless rats and human subjects","volume":"206","author":"Benfeldt E","year":"1999","journal-title":"Acta Derm. Venerol. Suppl. (Stockh.)"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050447"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.1999.02859.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.4269\/ajtmh.1951.s1-31.842","article-title":"Studies of diffusion of water through dead human skin; the effect of different environmental states and of chemical alterations of the epidermis","volume":"31","author":"Berenson G","year":"1951","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"e_1_2_10_16_1","first-page":"40","article-title":"Serum and urinary silver levels in thermal injury patients","volume":"101","author":"Boosalis M","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928\u20100987(96)00184\u20104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2003.09.021"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.12.021"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600741008"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600751115"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12455487"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00416669"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200710020-00011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069025"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.01.033"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2005.06989.x"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015559850135788"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155598441495"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00409406"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000252588"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105173(02)00540\u20109"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1965.01600120093023"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305\u20104179(81)90089\u20109"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.1995.tb00622.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247822"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104362.1976.tb00713.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004630\u2010199405000\u201000003"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12355351"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288163"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314995"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/1011\u20101344(92)85128\u2010H"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010003\u20100425\u20104"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1973.tb15450.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029806"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1992.tb03630.x"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12616623"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1984.tb04363.x"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.LAB.0000036874.83540.2B"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0272\u20100590(84)90145\u20103"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004032\u2010197507000\u201000009"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00424272"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-100100326"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2006.07319.x"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2006.00478.x"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700582"},{"key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2340\/0001555564439440","article-title":"Vascular effects of a local anesthetic mixture in atopic dermatitis","volume":"64","author":"Juhlin L","year":"1984","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_10_58_1","first-page":"18","article-title":"Absorption of lidocaine and prilocaine after application of a eutectic mixture of local anesthetics (EMLA) on normal and diseased skin","volume":"69","author":"Juhlin L","year":"1989","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015820600672"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015928225089"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20106915(86)90232\u20102"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.47.44"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105\u20101873.2003.0242.x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745\u20106673\u20101\u201017"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2006.027755"},{"key":"e_1_2_10_66_1","first-page":"21","article-title":"Skin pathology following epicutaneous exposure to seven organic solvents","volume":"3","author":"Kronevi T","year":"1981","journal-title":"Int. J. Tissue React."},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1984.tb15595.x"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1987.tb07493.x"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/js960350c"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1993.tb00482.x"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015843503746"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105173(99)00055\u20101"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2004.11.035"},{"key":"e_1_2_10_74_1","first-page":"9","article-title":"Dry skin in atopic dermatitis","volume":"177","author":"Linde YW","year":"1992","journal-title":"Acta Derm. Venereol. Suppl. (Stockh.)"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305\u20104179(83)90121\u20103"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2004.06084.x"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.18.1539"},{"key":"e_1_2_10_78_1","first-page":"120","volume-title":"Occupational Exposure to Pesticides: Report to the Federal Working Group on Pest Management from the Task Group on Occupational Exposure to Pesticides","author":"Maibach HI","year":"1974"},{"key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/jid.1956.118","article-title":"The transport of water through the human epidermis","volume":"27","author":"Mali J","year":"1956","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1973.tb07581.x"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1968.3"},{"key":"e_1_2_10_82_1","first-page":"359","volume-title":"Percutaneous Absorption","author":"McMaster J","year":"1985"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100215(200102)9999:9999<::AID\u2010IJC1154>3.0.CO;2\u2010K"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247977"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102133.2003.05163.x"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1998.tb03305.x"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018978232145"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010005\u20100555\u2010y"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010007\u20100788\u2010z"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105173(02)00554\u20109"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1963.01590170042007"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100536.2008.01348.x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20100562"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1984.tb01510.x"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2008.10.001"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/rpd\/ncm261"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.3109\/01480540903431457"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.9.2263\u20102270.2000"},{"key":"e_1_2_10_99_1","first-page":"521","article-title":"The effect of detergent on swelling of stratum corneum","volume":"28","author":"Putterman GJ","year":"1977","journal-title":"J. Soc. Cosmet. Chem."},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12482522"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105173(01)00766\u20109"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042\u20107158.1977.tb11434.x"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.121.12.1505"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00561126"},{"key":"e_1_2_10_105_1","first-page":"104","volume-title":"Current Research Problems in Psoriasis","author":"Schaefer H","year":"1984"},{"key":"e_1_2_10_106_1","first-page":"853","article-title":"Effects of surfactants and solvents on the permeability of epidermis","volume":"21","author":"Scheuplein R","year":"1970","journal-title":"J. Soc. Cosmet. Chem."},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12284280"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031\u20106989(85)90123\u20107"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378\u20105173(01)00805\u20105"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2005.12.019"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022\u2010202X.2005.23843.x"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.114.7.1029"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1979.tb08078.x"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12497937"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20103659(01)00359\u20105"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030100229"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.1077"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403\u2010003\u20100414\u20107"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1988.tb02461.x"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.1986.tb06242.x"},{"key":"e_1_2_10_121_1","first-page":"331","article-title":"Percutaneous absorption of hydrocortisone during exacerbation and remission of atopic dermatitis in adults","volume":"68","author":"Turpeinen M","year":"1988","journal-title":"Acta Derm. Venereol."},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031-8655(2000)072<0399:PIFKAL>2.0.CO;2"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031\u20108655(2000)072<0681:TAOAAH>2.0.CO;2"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1562\/0031\u20108655(2002)075<0172:SCOPIP>2.0.CO;2"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.10212"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.20004"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/37.10.1683"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(87)70106\u20106"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102230.2000.00652.x"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190\u20109622(83)70072\u20101"},{"key":"e_1_2_10_131_1","first-page":"429","volume-title":"4th International Symposium on Psoriasis: Proceedings of the Fourth International Symposium","author":"Wester R","year":"1987"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12556772"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12476269"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12491710"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523\u20101747.ep12627597"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/0923\u20101811(93)90076\u20102"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb15429.x"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.1773","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.1773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:57:12Z","timestamp":1760533032000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.1773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,10]]},"references-count":136,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1002\/jat.1773"],"URL":"https:\/\/doi.org\/10.1002\/jat.1773","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,10]]}}}