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Lipid peroxidation measurements were made in terms of malondialdehyde (MDA) formation in rat liver microsomes, or in the 9000 \u00d7 <jats:italic>g<\/jats:italic> supernatant. The inhibitory action of tetramethylthiuram monosulphide was considerably weaker. Carbon disulphide (CS<jats:sub>2<\/jats:sub>) inhibited the enzymatic and non\u2010enzymatic stimulated microsomal LPO by 4 orders less than the DTCs. In parallel with the inhibition of MDA formation, oxidative destruction of microsomal cytochrome P\u2010450 was delayed with increasing concentrations of the DTCs. A well\u2010correlated, non\u2010linear, semi\u2010logarithmic relation was found for the concentration\u2010activity relationship for all DTCs and CS<jats:sub>2<\/jats:sub>. As the DTCs inhibited LPO both in heat\u2010denatured and freshly prepared microsomes, it can be deduced that the DTCs intervene in a non\u2010enzymatic oxidation phase of the LPO. The DTC inhibitory action is attributed to a radical\u2010trap mechanism since LPO that has already been initiated was inhibited with the DTCs. However, more inhibitor is required to trap the radicals the later the DTC administration takes place.<\/jats:p>","DOI":"10.1002\/jat.2550010406","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T03:14:20Z","timestamp":1161141260000},"page":"215-219","source":"Crossref","is-referenced-by-count":7,"title":["The inhibitory action of dithiocarbamates and carbon disulphide on malondialdehyde formation resulting from lipid peroxidation in rat liver microsomes"],"prefix":"10.1002","volume":"1","author":[{"given":"K. J.","family":"Freundt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. G.","family":"R\u00f6mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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