{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:05:59Z","timestamp":1761523559241,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":8260,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1983,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Symphytum officinale<\/jats:italic> L. (Boraginaceae) is a medicinal plant widely used in therapy. Its roots, described in the <jats:italic>Polish Pharmacopoeia<\/jats:italic><jats:sup>1<\/jats:sup> as <jats:italic>Radix symphyti<\/jats:italic>, are recommended as expectorants, especially for children. Aqueous solutions of three alkaloid fractions obtained from infusions of <jats:italic>Symphytum officinale<\/jats:italic> L. root were tested for their antimitotic and mutagenic activity in meristematic cells of the lateral roots of <jats:italic>Vicia faba<\/jats:italic> L., var <jats:italic>minor<\/jats:italic>. Lasiocarpine, a proven carcinogen, served as a positive control. Mutagenic effects were induced by lasiocarpine, by the alkaloidal fraction I and by diluted infusions from <jats:italic>Radix symphyti<\/jats:italic>. Fraction III had only antimitotic effect. The biological activity of the tested solutions is discussed in relation to the relevant literature.<\/jats:p>","DOI":"10.1002\/jat.2550030304","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T13:42:12Z","timestamp":1160833332000},"page":"127-130","source":"Crossref","is-referenced-by-count":10,"title":["Mutagenic effects of aqueous extracts of <i>Symphytum officinale<\/i> L. and of its alkaloidal fractions"],"prefix":"10.1002","volume":"3","author":[{"given":"Miros\u0142awa","family":"Fumanowa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Guzewska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Be\u0142dowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Polish Pharmacopoeia 4th Edn pp.402\u2013403 Warsaw (1971)."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.16.2512"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)97225-X"},{"key":"e_1_2_1_5_2","first-page":"47","article-title":"Investigations of Radix symphyti for iasiocarpine content","volume":"26","author":"Debska W.","year":"1980","journal-title":"Herba Pol."},{"key":"e_1_2_1_6_2","first-page":"391","article-title":"Z\u00fcr m\u00f6glichen T\u00f6xizit\u00e4t und Kancerogenit\u00e4t handel s\u00fcblichen Drogen","volume":"119","author":"R\u00f6der E.","year":"1979","journal-title":"Dtsch. Apoth. Ztg"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1097287"},{"key":"e_1_2_1_8_2","first-page":"187","volume-title":"The Pyrrolizidine Alkaloids, Their Chemistry, Pathogenicity and Other Biological Properties","author":"Bull L. B.","year":"1968"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0031-6997(25)06884-X","article-title":"The toxic actions of pyrrolizidine (Senecio) alkaloids","volume":"22","author":"McLean E. K.","year":"1970","journal-title":"Pharmacol. 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J.","year":"1972","journal-title":"Cancer Res."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/53.5.1415"},{"key":"e_1_2_1_20_2","first-page":"467","article-title":"Induction of hepatic tumors in rats by senkirkine and symphytine","volume":"63","author":"Hirono I.","year":"1979","journal-title":"J. Nitl. Cancer Inst."},{"key":"e_1_2_1_21_2","first-page":"865","article-title":"Carcinogenic activity of Symphytum officinale","volume":"61","author":"Hirono I.","year":"1978","journal-title":"J. Natl Cancer Inst."},{"key":"e_1_2_1_22_2","first-page":"71","article-title":"Alkaloids of Cynoglossum officinale L. I and H. Dissert","volume":"16","author":"Jerzmanowska Z.","year":"1964","journal-title":"Pharm. Pharmacol."},{"key":"e_1_2_1_23_2","unstructured":"J.Gotawska\u2013Dobija Research on chemism of Symphytum officinale root. 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