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Albino rats (F<jats:sub>1<\/jats:sub>), which had been prenatally exposed by maternal inhalation to teratogenic (200 and 100 mgm<jats:sup>\u22123<\/jats:sup>) and subteratogenic (10 and 0.03 mg m<jats:sup>\u22123<\/jats:sup>) concentrations of CS<jats:sub>2<\/jats:sub>, were reared until maturity and mated to produce an F<jats:sub>2<\/jats:sub> generation. During pregnancy the F<jats:sub>1<\/jats:sub> females were again subjected to CS<jats:sub>2<\/jats:sub> exposure at the same concentrations as the F<jats:sub>0<\/jats:sub> females throughout gestation. Pre\u2010and postnatal development of F<jats:sub>1<\/jats:sub> and F<jats:sub>2<\/jats:sub> generations, as well as the corresponding maternal effects, were studied. Embryonic lethality, weight, congenital malformations, indices of lipid and energy metabolism, DNA and some liver drug metabolizing enzymes in maternal and fetal tissues were studied at term. Postnatal viability, physical and behavioral development, and hexobarbital sleeping time of the progeny were evaluated. Comparisons of CS<jats:sub>2<\/jats:sub> effect on F<jats:sub>1<\/jats:sub> and F<jats:sub>2<\/jats:sub> generations were performed. A marked increase in CS<jats:sub>2<\/jats:sub>\u2010induced teratogenicity was found in the F<jats:sub>2<\/jats:sub> generation, together with retarded development of MFO system and increased postnatal behavioral effects. The results point to intrauterine sensitization of progeny to CS<jats:sub>2<\/jats:sub>\u2010This effect is discussed in the light of possible interference of the agent with the hormonal programming of intrauterine development.<\/jats:p>","DOI":"10.1002\/jat.2550030502","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T13:53:49Z","timestamp":1160834029000},"page":"223-229","source":"Crossref","is-referenced-by-count":16,"title":["Carbon disulphide intrauterine sensitization"],"prefix":"10.1002","volume":"3","author":[{"given":"Sonia","family":"Tabacova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojidar","family":"Nikiforov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liudmila","family":"Balabaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(79)90111-7"},{"key":"e_1_2_1_3_2","article-title":"Low\u2010dose preadmini\u2010stration of cadmium prevents cadmium\u2010induced exencephalia","volume":"10","author":"Semba R.","year":"1974","journal-title":"Teratology"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(78)90086-3"},{"key":"e_1_2_1_5_2","first-page":"121","article-title":"Hazards for the progeny after maternal exposure to low CS2 concentrations","volume":"3","author":"Tabacova S.","year":"1981","journal-title":"G. 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