{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T03:02:12Z","timestamp":1770433332584,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":8138,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A variety of low molecular weight aliphatic chlorinated hydrocarbons have a history of use in the processing of foods, and their presence in potable water supplies has also been demonstrated. In this study, the relative uptake of four different aliphatic chlorinated hydrocarbons (methylene chloride, dichloroethane, chloroform and trichloroethylene) was studied after administration, by intragastric intubation, at the same dose level as corn\u2010oil or aqueous solutions. Serial blood samples were collected over a 5\u2010h period and uptake was assessed as the calculated area under blood concentration\u2010time curves. A significant decrease in the rate and extent of uptake was observed for the compounds when administered as an oil solution as compared with an aqueous solution. Lower peak concentrations and an increase in the time taken to reach peak concentration, after dosing with corn oil solutons, was also observed.<\/jats:p>","DOI":"10.1002\/jat.2550030506","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T13:53:49Z","timestamp":1160834029000},"page":"249-253","source":"Crossref","is-referenced-by-count":57,"title":["Effect of vehicle on the pharmacokinetics and uptake of four halogenated hydrocarbons from the gastrointestinal tract of the rat"],"prefix":"10.1002","volume":"3","author":[{"given":"Jim R.","family":"Withey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian T.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Fundamentals of Drug Metabolism and Drug Disposition","author":"Schanker L. 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Off. Anal. Chem."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4565.1977.tb00265.x"},{"key":"e_1_2_1_12_2","first-page":"825","article-title":"Collaborative study of gas chromatographic determination of methylene chloride, ethylene dichloride and trichloroethylene in spice oieo resins","volume":"51","author":"Roberts L. A.","year":"1968","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"e_1_2_1_13_2","volume-title":"A Report of the Safe Drinking Water Committee","author":"National Academy of Sciences","year":"1977"},{"key":"e_1_2_1_14_2","first-page":"15926","volume":"44","author":"Federal Register","year":"1979","journal-title":"Environmental Protection Agency: Water Quality Criteria. Request for comments"},{"key":"e_1_2_1_15_2","first-page":"313","article-title":"Chlorinated aliphatic hydrocarbons used in the food industry: The comparative pharmacokinetics of methylene chloride, 1,2\u2010dichloroethane, chloroform and trichloroethylene after i.v. administration in the rat","volume":"3","author":"Withey J. R.","year":"1980","journal-title":"J. Environ. Pathol. Toxicol."},{"key":"e_1_2_1_16_2","volume-title":"Applied Regression Analysis","author":"Draper N. R.","year":"1966"},{"key":"e_1_2_1_17_2","volume-title":"The Halogenated Hydrocarbons of Industrial and Toxicological Importance","author":"Van Oettingen W. 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