{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:53:41Z","timestamp":1772816021243,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":8015,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heavy distillate (HD), the highest\u2010boiling coal liquid from the solvent\u2010refined coal\u2010II process (SRC\u2010II), was administered by intragastric (IG) intubation to pregnant rats. Five dose levels of HD (0.09, 0.14, 0.18, 0.36 and 0.74 g kg<jats:sup>\u22121<\/jats:sup>), were given daily from 12 to 16 days of gestation and the rats were killed at 20 days of gestation. Maternal body weights and weights of the liver, kidneys, spleen, adrenals, thymus, ovaries and the gravid uterus were obtained. Gravid uteri were evaluated for prenatal mortality. Live fetuses were examined for malformations and weighed; fetal lungs were excised and weighed. Maternal (extragestational) weight gains and thymic weights diminished in all groups that received the SRC material. Adrenal weights were increased in all treated animals, except for those in the lowest\u2010dose group (0.9 g kg<jats:sup>\u22121<\/jats:sup>). There was significant maternal mortality at 0.74 g kg<jats:sup>\u22121<\/jats:sup> and increased intrauterine mortality at doses of 0.37 and 0.74 g kg<jats:sup>\u22121<\/jats:sup>. Placental weight was depressed, and the incidence of fetal anomalies was increased at 0.14 g kg<jats:sup>\u22121<\/jats:sup> and all higher dose levels.<\/jats:p>","DOI":"10.1002\/jat.2550040111","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T13:58:56Z","timestamp":1160834336000},"page":"57-62","source":"Crossref","is-referenced-by-count":20,"title":["Developmental toxicity following oral administration of a high\u2010boiling coal liquid to pregnant rats"],"prefix":"10.1002","volume":"4","author":[{"given":"P. L.","family":"Hackett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. N.","family":"Rommereim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Sikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(81)90054-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-2361(81)90197-6"},{"key":"e_1_2_1_4_2","first-page":"471","volume-title":"Coal Conversion and the Environment: Chemical, Biomedical and Ecological Considerations","author":"Renne R. A.","year":"1980"},{"key":"e_1_2_1_5_2","first-page":"A27","article-title":"Developmental toxicity of solvent\u2010refined coal\u2010related hydrocarbons","volume":"48","author":"Andrew F. D.","year":"1979","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550020509"},{"key":"e_1_2_1_7_2","first-page":"262","volume-title":"Teratology Principles and Techniques","author":"Wilson J. G.","year":"1965"},{"key":"e_1_2_1_8_2","first-page":"37","article-title":"Detection of visceral alterations in mammalian fetuses","volume":"9","author":"Staples R. E.","year":"1974","journal-title":"Teratology"},{"key":"e_1_2_1_9_2","first-page":"62","article-title":"Refinements in rapid clearing technique in the KOH\u2010alizarin red S method for fetal bone","volume":"39","author":"Stables R. E.","year":"1964","journal-title":"Stain Technol."},{"key":"e_1_2_1_10_2","first-page":"107","volume-title":"Principles and Procedures of Statistics","author":"Steel R. G. D.","year":"1960"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/41.1-2.133"},{"key":"e_1_2_1_12_2","volume-title":"Non\u2010Parametric Statistics for Behavioural Sciences","author":"Siegel S.","year":"1956"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7233204"},{"key":"e_1_2_1_14_2","first-page":"15","volume-title":"Pacific Northwest Laboratory Report for 1981 to the DOE Office of Energy Research","author":"Springer D. L.","year":"1982"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1542\/peds.1.4.462","article-title":"Multiple congenital malformations: A consideration of etiologic factors","volume":"1","author":"Warkany J.","year":"1948","journal-title":"Pediatrics"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230210"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-123-31578"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/107.5.862"},{"key":"e_1_2_1_19_2","first-page":"604","volume-title":"Congenital Malformations","author":"Warkany J.","year":"1971"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287398109530115"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550040111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550040111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:04:55Z","timestamp":1760529895000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550040111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,2]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,2]]}},"alternative-id":["10.1002\/jat.2550040111"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550040111","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,2]]}}}