{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:48:52Z","timestamp":1760575732850,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":7711,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1984,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of 3\u2010methylxanthine, the pharmacologically active metabolite of theophylline, on the kidneys of Wistar rats after short\u2010term administration were studied. 3\u2010Methylxanthine was administered in oral doses of 0 (control), 50, 100 and 200 mg per kg per day for 1, 8 and 16 days. The kidneys were examined by light and electron microscopy. Tubular necrosis was noticed at a dose level of 100 mg kg<jats:sup>\u22121<\/jats:sup> after 16 days and at a dose level of 200 mg kg<jats:sup>\u22121<\/jats:sup> after 8 days. Elevated values of serum urea were found after 1 day of treatment with a dose of 200 mg kg<jats:sup>\u22121<\/jats:sup> and after 16 days with a dose of 100 mg kg<jats:sup>\u22121<\/jats:sup>. Elevated values of serum creatinine were detected after 8 days of treatment with a dose of 200 mg kg<jats:sup>\u22121<\/jats:sup>. The results indicate dose\u2010 and time\u2010related renal failure following administration of 3\u2010methylxanthine.<\/jats:p>","DOI":"10.1002\/jat.2550040605","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T14:20:41Z","timestamp":1160835641000},"page":"304-307","source":"Crossref","is-referenced-by-count":3,"title":["Kidney toxicity of 3\u2010methylxanthine in the rat"],"prefix":"10.1002","volume":"4","author":[{"given":"R.","family":"Sellman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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