{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:48:06Z","timestamp":1771519686330,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T00:00:00Z","timestamp":1138752000000},"content-version":"vor","delay-in-days":7367,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1985,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pretreatment of strips of rabbit aorta with 10<jats:sup>\u22123<\/jats:sup> <jats:sc>M<\/jats:sc> sodium cyanide reduced contractions to 10<jats:sup>\u22128<\/jats:sup> through 10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc> norepinephrine (NE) added cumulatively. This antagonism by cyanide was not altered by 4 \u00d7 10<jats:sup>\u22126<\/jats:sup> <jats:sc>M<\/jats:sc> ouabain or verapamil, suggesting a lack of involvement of Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup> ATPase or of calcium influx in the antagonism. Cyanide potentiated contractions caused by 3 \u00d7 10<jats:sup>\u22123<\/jats:sup> <jats:sc>M<\/jats:sc> potassium, but reduced contractions induced by higher potassium concentrations. Because the antagonism of higher concentrations of potassium and NE were similar, it seems that selective actions on different calcium pools are possibly not involved in the antagonism of agonist\u2010induced contractions. 10<jats:sup>\u22122<\/jats:sup> <jats:sc>M<\/jats:sc> cyanide contracted rabbit aorta with a mean contraction 16% of that induced by 10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc> NE. These contractions were potentiated by pretreatment with 4 \u00d7 10<jats:sup>\u22126<\/jats:sup> <jats:sc>M<\/jats:sc> ouabain and 4 \u00d7 10<jats:sup>\u22126<\/jats:sup> m verapamil but were unaffected by the serotonin antagonist 2\u2010bromo lysergic acid diethylamide, 10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc> (2\u2010BrLSD), the <jats:italic>alpha<\/jats:italic> adrenergic antagonist phentolamine, 4 \u00d7 10<jats:sup>\u22125<\/jats:sup> <jats:sc>M<\/jats:sc>, the H<jats:sub>1<\/jats:sub> antihistaminic pyrilamine, 10<jats:sup>\u22125<\/jats:sup> <jats:sc>M<\/jats:sc>, or the antimuscarinic atropine, 10<jats:sup>\u22126<\/jats:sup> <jats:sc>M<\/jats:sc>. The contractions were reduced by 10<jats:sup>\u22124<\/jats:sup> <jats:sc>M<\/jats:sc> 4,4\u2032\u2010di\u2010isothiocyano\u20102,2\u2032\u2010stilbene disulfonic acid (DIDS) or chlorpromazine. The reduction may be due to a blockade of anionic channel mechanisms facilitating entry of cyanide into the vascular smooth muscle cell, as both of these agents can block anionic channels in other tissues.<\/jats:p>","DOI":"10.1002\/jat.2550050607","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T18:53:30Z","timestamp":1161024810000},"page":"372-377","source":"Crossref","is-referenced-by-count":8,"title":["The mechanisms of action of cyanide on the rabbit aorta"],"prefix":"10.1002","volume":"5","author":[{"given":"Casey P.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven I.","family":"Baskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Franz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1152\/ajplegacy.1963.204.2.309","article-title":"Increase in cerebral blood flow produced by low dosages of cyanide","volume":"204","author":"Russek M.","year":"1963","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1979.10667431"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00569238"},{"key":"e_1_2_1_5_2","first-page":"410","article-title":"The effect of cyanide on isolated aorta strips from the dog, rabbit and ferret","volume":"4","author":"Robinson C. P.","year":"1984","journal-title":"The Toxicologist"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-102-25187"},{"key":"e_1_2_1_7_2","first-page":"374","article-title":"Antagonism of cyanide intoxication by chlorpromazine","volume":"17","author":"Guth P. S.","year":"1958","journal-title":"Fed. Am. Soc. Exp. Biol."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(76)90029-6"},{"key":"e_1_2_1_9_2","first-page":"533","article-title":"Antagonism of cyanide toxicity by phenoxybenzamine","volume":"35","author":"Burrows G. E.","year":"1976","journal-title":"Fed. Proc."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.27.470"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-3565(25)05163-8","article-title":"Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite, and other drugs","volume":"108","author":"Furchgott R. I.","year":"1953","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_12_2","first-page":"261","article-title":"Mechanism of potassium relaxation of arterial muscle","volume":"14","author":"Bonacorrsi A.","year":"1977","journal-title":"Blood Vessels"},{"key":"e_1_2_1_13_2","first-page":"198","article-title":"Potassium\u2010induced relaxation as an indicator of Na+\u2010K+ ATPase activity in vascular smooth muscle","volume":"15","author":"Webb R. C.","year":"1978","journal-title":"Blood Vessels"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.001021"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.53.2.168"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586221"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.47.1.173"},{"key":"e_1_2_1_18_2","first-page":"295","volume-title":"Muscle","author":"Daniel E. E.","year":"1965"},{"key":"e_1_2_1_19_2","first-page":"269","volume-title":"Muscle","author":"Hinke J. A. M.","year":"1965"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.0491299"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0022-3565(25)27843-0","article-title":"Differential effects of calcium removal upon vascular smooth muscle contraction induced by norepinephrine, histamine and potassium","volume":"159","author":"Hudgins P. M.","year":"1968","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/10641967809068611"},{"key":"e_1_2_1_23_2","first-page":"240A","article-title":"Effects of sustained increases in extracellular potassium on coronary resistance in intact dog hearts","volume":"24","author":"Schuchleib R.","year":"1976","journal-title":"Clin. Res."},{"key":"e_1_2_1_24_2","first-page":"153","article-title":"Effects of reserpinization, surgical denervation and in vivo chemical denervation with 6\u2010hydroxydopamine on the contractile response of isolated rabbit ear artery to propranolol","volume":"18","author":"Purdy R. E.","year":"1981","journal-title":"Blood Vessels"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01908132"},{"key":"e_1_2_1_26_2","first-page":"346","article-title":"Herzglykoside als Hammstoffe fur den aktiven Kalium und Natriumtransport durch die Erythrocyten\u2010membrane","volume":"11","author":"Schatzmann H. J.","year":"1953","journal-title":"Helv. Physiol. Pharmacol. Acta"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(68)90023-0"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1969.sp008702"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008467"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1970.sp009153"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(70)90029-5"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BFb0034293"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(80)90005-X"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(81)90146-2"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(81)90230-3"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(82)90198-5"},{"key":"e_1_2_1_37_2","first-page":"802","article-title":"Dopamine antagonist effect of verapamil on isolated perfused rabbit ear artery","volume":"22","author":"Johnson C. E.","year":"1983","journal-title":"J. Pharmacol. Exp. Pharmacol."},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1979.sp012677"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01867863"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870088"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585203"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(77)90040-2"},{"key":"e_1_2_1_43_2","first-page":"175","volume-title":"Membrane Transport in Red Cells","author":"Fortes P. A. G.","year":"1977"},{"key":"e_1_2_1_44_2","volume-title":"Physiology and Pathology of Electrolyte Metabolism","author":"Wieth J. O.","year":"1982"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1979.tb02309.x"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550050607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550050607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T14:42:45Z","timestamp":1760539365000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550050607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,12]]}},"alternative-id":["10.1002\/jat.2550050607"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550050607","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12]]}}}