{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:53:42Z","timestamp":1760576022088,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":7225,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1986,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When rats were exposed to 2 mg l<jats:sup>\u22121<\/jats:sup> (\u02dc640 ppm) of carbon dislfide (CS<jats:sub>2<\/jats:sub>) for 4 h, the concentration of free CS<jats:sub>2<\/jats:sub> in the red blood cells (RBCs) approached a plateau within 2 h. Free CS<jats:sub>2<\/jats:sub> in plasma reached a steady state concentration within 15 min of exposure. More than 90% of the free CS<jats:sub>2<\/jats:sub> in blood was found in the RBCs regardless of the length of exposure. <jats:italic>In vitro<\/jats:italic> studies showed that about 90% of the free CS<jats:sub>2<\/jats:sub> partitioned into the RBCs regardless of whether the CS<jats:sub>2<\/jats:sub> was added first to the plasma or directly to the RBCs. Hence, it appears that the RBC is the major carrier of CS<jats:sub>2<\/jats:sub> in blood. It was found that 98% of the free CS<jats:sub>2<\/jats:sub> in red blood cell lysates was associated with hemoglobin. Free CS<jats:sub>2<\/jats:sub> in RBCs was readily partitioned into olive oil (RBCs\/oil=1\/6), less readily into the plasma (RBCs\/plsma=12\/1), and only to a small extent into phosphate buffer (RBCs\/buffer=39\/1). The extraction of free CS<jats:sub>2<\/jats:sub>\u2010loaded RBCs into albumin solution increased with increasing albumin concentrations. CS<jats:sub>2<\/jats:sub> can be extracted with buffer, protein solution, and oil, indicating that CS<jats:sub>2<\/jats:sub> in RBCs can be transferred to the medium in which the RBCs contact. It is proposed that RBCs may also play an important role in the transport of CS<jats:sub>2<\/jats:sub> from lung to tissues and vice versa. The possible role of RBCs in the transport of other organic solvents in the blood is also discussed.<\/jats:p>","DOI":"10.1002\/jat.2550060203","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T14:47:26Z","timestamp":1160837246000},"page":"81-86","source":"Crossref","is-referenced-by-count":6,"title":["The role of the red blood cell in the transport of carbon disulfide"],"prefix":"10.1002","volume":"6","author":[{"given":"Chiu\u2010Wing","family":"Lam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Distefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald A.","family":"Morken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"235","article-title":"Carbon disulphide poisoning in viscose rayon factories","volume":"11","author":"Vigliani E. 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