{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:00:21Z","timestamp":1760576421066,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":7103,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1986,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 5\u2010month treatment of rats with ethanol (10% solution in drinking water) stimulated aniline p\u2010hydroxylase and the microsomal ethanol oxidizing system (MEOS) by 140 and 70%, respectively, cytochrome P\u2010450 by 22% and accompanied by lipid peroxidation by 40% in microsomes. It also caused smooth endoplasmic reticulum (SER) proliferation and rough endoplasmic reticulum (RER) degranulation in hepatocytes. Repeated inhalatory exposure of rats to 1.5 g\/m<jats:sup>3<\/jats:sup> of CS<jats:sub>2<\/jats:sub>, 5h daily, 5 days a week for 5 months decreased aniline p\u2010hydroxylase and MEOS by 70 and 55% respectively, doubled hexobarbital sleeping time and depressed cytochrome P\u2010450 by 30% and its conversion to cytochrome P\u2010420; these effects were accompanied by the appearance of cytochrome P\u2010420, the intensification of lipid peroxidation in microsomes and some degranulation of RER in hepatocytes. Combined exposure of rats to ethanol and CS<jats:sub>2<\/jats:sub> resulted in a significant potentiation of the inhibitory effects of CS<jats:sub>2<\/jats:sub> on cytochrome P\u2010450 mono\u2010oxygenase and MEOS but with enhancement of CS<jats:sub>2<\/jats:sub> effects on the liver microsomal mono\u2010oxygenase, but CS<jats:sub>2<\/jats:sub> decreased the effect of ethanol on SER proliferation. The interaction both on the biochemical and the morphological level can be explained with the ethanol\u2010stimulated biotransformation of CS<jats:sub>2<\/jats:sub> to reactive electrophilic derivative(s), the subsequent destruction of cytochrome P\u2010450 to cytochrome P\u2010420 and the intensification of lipid peroxidation.<\/jats:p>","DOI":"10.1002\/jat.2550060412","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T14:59:55Z","timestamp":1160837995000},"page":"297-302","source":"Crossref","is-referenced-by-count":3,"title":["Combined effect of ethanol and carbon disulphide on cytochrome P\u2010450 monooxygenase, lipid peroxidation and ultrastructure of the liver in chronically exposed rats"],"prefix":"10.1002","volume":"6","author":[{"given":"Teresa","family":"Wro\u0144ska\u2010Nofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Klimczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna M.","family":"Wi\u015bniewska\u2010Knypl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Jajte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Opalska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"54","volume-title":"Environmental Health Criteria: Carbon Disulfide","author":"World Health Organization","year":"1979"},{"issue":"93","key":"e_1_2_1_3_2","article-title":"Inhibition of aminopyrine demethylation following inhalation of low doses of carbon disulfide in humans","volume":"270","author":"Mack T.","year":"1971","journal-title":"Naunyn\u2010Schmiedebergs Arch. Pharmac."},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(69)90368-2"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(73)90037-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1977.tb02085.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.162.3854.690"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1016\/S0021-9258(18)63099-6","article-title":"Hepatic microsomal ethanol\u2010oxidizing systems. In vitro characteristic and adaptive properties in vivo","volume":"245","author":"Lieber C. S.","year":"1970","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_9_2","first-page":"2060","article-title":"Differences in hepatic and metabolic changes after acute and chronic alcohol consumption","volume":"34","author":"Lieber C. S.","year":"1975","journal-title":"Fed. Proc."},{"key":"e_1_2_1_10_2","first-page":"24","article-title":"On possible adverse reactions following use of some drugs by persons handling carbon disulfide (in Russian)","volume":"9","author":"Lazarev N. J.","year":"1965","journal-title":"Gig. Tr. Prof. Zabol."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-3450-7_27"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/00498257509056121"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(71)80571-9"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)82244-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0926-6593(66)80056-5"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2944(80)90040-X"},{"key":"e_1_2_1_18_2","first-page":"1449","volume-title":"Methods on Enzymatic Analysis","author":"Bernt E.","year":"1974"},{"key":"e_1_2_1_19_2","first-page":"11","volume-title":"Diets for Animal Experiments","author":"S\u00f3s J.","year":"1974"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90004-6"},{"key":"e_1_2_1_21_2","first-page":"95","article-title":"Effect of phenobarbitone and starvation on hepatotoxicity in rats exposed to carbon disulphide vapour","volume":"29","author":"Magos L.","year":"1972","journal-title":"Brit. J. Industr. Med."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00409362"},{"key":"e_1_2_1_23_2","first-page":"307","volume-title":"Cytochrome P\u2010450, Biochemistry, Biophysics and Induction. Proceedings of the 5th International Conference on Cytochrome P\u2010450, Budapest, Hungary, August 21\u201024, 1985","author":"Wro\u0144ska\u2010Nofer T.","year":"1985"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(84)90014-6"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(85)90054-2"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550060412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550060412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T18:51:26Z","timestamp":1760554286000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550060412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,8]]}},"alternative-id":["10.1002\/jat.2550060412"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550060412","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1986,8]]}}}