{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:59:58Z","timestamp":1760576398340,"version":"build-2065373602"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":7042,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrophobic tributylin (TBT) compounds at concentrations greater than 10 \u03bc<jats:sc>M<\/jats:sc> used hemolysis of human erythrocytes and formed structures in plasma membranes. The mercapto compounds, \u03b2\u2010mercaptoethanol (\u03b2 MER), 2,3\u2010dimercaptopropanol (BAL), 2,3\u2010dimercapto\u20101\u2010propane sulfonate (DMPS), DL\u2010dithiothreitol (DTT), and meso\u20102,3\u2010dimercaptosuccinic acid (DMSA) were examined for their ability to inhibit TBT mediated hemolysis. The relative order of effectiveness for inhibition of TBT mediated hemolysis was BAL&gt;DTT&gt;DMSA&gt;DMPS&gt;\u03b2 MER. A four\u2010fold excess of BAL over TBT prevented hemolysis for 4 hrs and addition of BAL 0.5 hr after TBT reduced the rate of hemolysis. The number of membrane associated TBT aggregates observed per cell profile decreased as the BAL concentration increased from 0 to 100 \u03bc<jats:sc>M<\/jats:sc>. However, the mean diameter of TBT aggregates nearly doubled in erythrocyte suspensions at 100 \u03bc<jats:sc>M<\/jats:sc> BAL. Reactions of dimercapto compounds with lipophilic TBT aggregates may depend on their relative lipid solubilities. Also, conversion of the weak Lewis acid, TBT, from a four to a five or six\u2010coordinate tin adduct by the dimercapto Lewis bases used could also be a factor slowing hemolysis rates.<\/jats:p>","DOI":"10.1002\/jat.2550060511","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T15:07:09Z","timestamp":1160838429000},"page":"363-370","source":"Crossref","is-referenced-by-count":26,"title":["Inhibition of tributyltin mediated hemolysis by mercapto compounds"],"prefix":"10.1002","volume":"6","author":[{"given":"Bryan H.","family":"Gray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Porvaznik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanfong H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlyle","family":"Flemming","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"57","volume-title":"Reviews on Silicon, Germanium Tin and Lead Compounds","author":"Evans C. 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