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We assessed the effects of these drugs on the acute toxicity of parathion in rats by measuring the rate of survival at 24 h after the administration of the oral LD50 of parathion to four groups of rats: control and pretreated with the aforementioned drugs. Additional rats of these groups were used to measure the capability of liver isolated microsomes to transform p\u2010nitroanisole to p\u2010nitrophenol. In the control and cimetidine groups we also measured the transformation of parathion to paraoxon and p\u2010nitrophenol by the liver microsomes. Phenobarbital increased the survival 100% whereas cimetidine and SKF 525 A dramatically potentiated parathion toxicity. Phenobarbital increased the formation of p\u2010nitrophenol but cimetidine and SKF\u2010525 A produced the opposite effect. Paraoxon and p\u2010nitrophenol from parathion were decreased by cimetidine. Our results strongly suggest that parathion itself is largely responsible of its toxicity and the inhibition of its metabolism is harmful rather than beneficial.<\/jats:p>","DOI":"10.1002\/jat.2550060604","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T07:55:49Z","timestamp":1160985349000},"page":"401-404","source":"Crossref","is-referenced-by-count":6,"title":["Cimetidine enhances and phenobarbital decreases parathion toxicity"],"prefix":"10.1002","volume":"6","author":[{"given":"Marisabel","family":"Mourelle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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