{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:57:59Z","timestamp":1760576279936,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":6799,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The N\u2010phenylsuccinimides are being evaluated as experimental agricultural fungicides. The purpose of this study was to examine the relationship between the electron withdrawing or electron donating properties of phenyl ring substituents on meta\u2010substituted N\u2010phenylsuccinimide (NPS) derivatives and the nephrotoxic potential of the corresponding fungicides. Male Fischer 344 rats were administered a single intraperitoneal injection of a succinimide (0.4 or 1.0 mmol\/kg) or vehicle (sesame oil, 2.5 ml\/kg), and renal function monitored at 24 and 48 hr. Non\u2010halogen\u2010substituted NPS derivatives produced little evidence of nephrotoxicity at the doses used in this study. Among the meta\u2010halogen derivatives of NPS, N\u2010(3\u2010chlorophenyl)succinimide (NCPS) was the most nephrotoxic. NCPS\u2010induced nephrotoxicity was characterized by diuresis, proteinuria, hematuria, elevated blood urea nitrogen (BUN) concentration, decreased organic ion accumulation and proximal tubular necrosis. However, all renal effects produced by NCPS were mild to moderate. These results suggest that the electron withdrawing or donating property of a functional group is not a good predictor of the nephrotoxic potential for the corresponding fungicide. In addition, lipophilicity did not correlate with nephrotoxic potential for the meta\u2010substituted NPS derivatives evaluated in this study.<\/jats:p>","DOI":"10.1002\/jat.2550070302","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T11:30:53Z","timestamp":1160825453000},"page":"153-160","source":"Crossref","is-referenced-by-count":9,"title":["Structure\u2010nephrotoxicity relationships for meta\u2010substituted N\u2010phenylsuccinimides"],"prefix":"10.1002","volume":"7","author":[{"given":"David J.","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick I.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herng\u2010Hsiang","family":"Lo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vonda J.","family":"Teets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary O.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.35.1707"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.36.318"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(82)90038-5"},{"key":"e_1_2_1_5_2","first-page":"219","article-title":"Pathologic analysis of chemical nephritis in rats induced by N\u2010(3,5\u2010dichlorophenyl)succinimide","volume":"33","author":"Sugihara S.","year":"1975","journal-title":"Lab. Invest."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(84)90092-1"},{"key":"e_1_2_1_7_2","first-page":"425","article-title":"Experimental interstitial renal fibrosis in rats: nephritis induced by N\u2010(3,5\u2010dichlorophenyl)succinimide","volume":"64","author":"Barrett M. C.","year":"1983","journal-title":"Br. J. Exp. Path."},{"key":"e_1_2_1_8_2","first-page":"147","article-title":"Combination effect of citrinin and other chemicals on rat kidney tumorigenesis","volume":"67","author":"Shinohara Y.","year":"1976","journal-title":"Gann"},{"key":"e_1_2_1_9_2","first-page":"397","article-title":"Effect of N\u2010(3,5\u2010dichlorophenyl)succinimide on the histological pattern and incidence of kidney tumors produced by streptozptocin","volume":"68","author":"Shinohara Y.","year":"1977","journal-title":"Gann"},{"key":"e_1_2_1_10_2","first-page":"477","article-title":"Promotion of 2\u2010(ethylnitrosamino)ethanol\u2010induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N\u2010(3,5\u2010dichlorophenyl)succinimide but not with 2,3\u2010dibromo\u20101\u2010propanol phosphate","volume":"72","author":"Shirai T.","year":"1984","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(85)90140-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(85)90148-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(86)90129-3"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(85)90004-6"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0022-3565(25)29434-4","article-title":"Strain differences in metabolism and susceptibility to the nephrotoxic effects of methoxyflurane in rats","volume":"184","author":"Mazze R. I.","year":"1973","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_16_2","first-page":"48","article-title":"Nephrotoxicity of gentamicin","volume":"30","author":"Kosek J. C.","year":"1974","journal-title":"Lab. Invest."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(77)90005-9"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0048-3575(79)90081-6"},{"key":"e_1_2_1_19_2","unstructured":"D. J.Yang H. H.Lo V. J.Teets P. I.BrownandG. O.Rankin Nephrotoxicity of N\u2010(3 5\u2010dihalophenyl)succinimides in Fischer 344 rats.J. Toxicol. Environ. Health(in press)."},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90191-8"},{"key":"e_1_2_1_21_2","first-page":"720","article-title":"Effect of enzyme induction\/inhibition on N\u2010(3,5\u2010dichlorophenyl)\u2010succinimide\u2010induced nephrotoxicity in the Fischer 344 rat","volume":"44","author":"Rankin G. O.","year":"1985","journal-title":"Fed. Proc."},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(85)90113-1"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550070302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550070302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:54:49Z","timestamp":1760550889000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550070302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["10.1002\/jat.2550070302"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550070302","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}