{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:00:16Z","timestamp":1760576416919,"version":"build-2065373602"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":6677,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1987,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This paper describes a computer\u2010controlled system to regulate solvent vapour concentrations in experimental inhalation devices. This system consists of an exposure chamber, a bubbler with a mass flow\u2010meter, a monitor gas chromatograph and a computer. The frequency of automatic sampling was dependent upon the retention time of test materials. Flow\u2010rate was corrected through a computer regulated bubbler as soon as the mean chamber concentration varied by more tham 2.5% of a command level. Regulation coefficients were calculated by relating the concentration of vapours sampled with adsorbent tubes to the mean peak areas given by the mantor gas chromatograph. They were then fed into the computer allowing the actual concentration to be adjusted to the command level. Deliberately induced fluctuations in the level of acetone, ethanol and trichloroethylene, either sudden or progressive, were satisfactorily corrected as were fluctuations occurring normally during repeated exposures to ethanol. Variations were generally inferior to 5% of the command level.<\/jats:p>","DOI":"10.1002\/jat.2550070502","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T11:38:14Z","timestamp":1160825894000},"page":"297-302","source":"Crossref","is-referenced-by-count":0,"title":["A programmed feedback control of solvent vapour concentrations in experimental inhalation chambers"],"prefix":"10.1002","volume":"7","author":[{"given":"P.","family":"Bonnet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Delcourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Jeandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"de Ceaurriz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1289\/ehp.845623","article-title":"Inhalation exposure methodology","volume":"56","author":"Phalen R. F.","year":"1964","journal-title":"Environ. Health Perspect."},{"key":"e_1_2_1_3_2","unstructured":"OECD Guidelines for testing of chemicals. No 406 Paris (1981)."},{"key":"e_1_2_1_4_2","unstructured":"EEC Toxicit\u00e9 aigu\u00eb\u2013Administration par inhalation.J. Off. Commun. Euro.Directive 79\/831\/CEE Annexe V No L 259\/10 L 259\/28 (1979)."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/15298668191419992"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01607486"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/15298668491399523"},{"key":"e_1_2_1_8_2","first-page":"249","article-title":"Toxicit\u00e9 aigu\u00eb compar\u00e9e par inhalation des principaux solvents aliphatiques chlor\u00e9s","volume":"39","author":"Gradiski D.","year":"1978","journal-title":"Arch. Mal. Profess."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/28.1.61"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/30.1.103"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550070502","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550070502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:10:08Z","timestamp":1760555408000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550070502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,10]]}},"alternative-id":["10.1002\/jat.2550070502"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550070502","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1987,10]]}}}