{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:32:10Z","timestamp":1760574730462,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":6188,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1989,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Marmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. Although muscle damage alone caused small increases in the plasma levels of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (ICDH), only the isoenzyme analysis of ICDH can differentiate definitely between liver and muscle damage. Only very severe muscle damage can increase the plasma concentration of this enzyme but, in this case, the elevation of plasma creatinine kinase levels helps differentiation. It is recommended that the elevation of ICDH is the most specific indicator of hepatic damage in the marmoset.<\/jats:p>","DOI":"10.1002\/jat.2550090107","type":"journal-article","created":{"date-parts":[[2006,10,12]],"date-time":"2006-10-12T19:58:12Z","timestamp":1160683092000},"page":"33-37","source":"Crossref","is-referenced-by-count":2,"title":["The diagnostic usefulness of isocitrate dehydrogenase (ICDH) in the marmoset (<i>Callithrix jacchus<\/i>)"],"prefix":"10.1002","volume":"9","author":[{"given":"C. W.","family":"Davy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Fulleylove","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Edmunds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Eichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rushton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Tudor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"49","volume-title":"Methods of Enzymatic Analysis","author":"Wieme R. J.","year":"1983"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367782781110214"},{"key":"e_1_2_1_4_2","first-page":"672","article-title":"Metabolic alterations in organ junction","volume":"58","author":"Plaa G.","year":"1975","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(78)90014-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.2460\/ajvr.1981.42.04.674","article-title":"Variations of plasma enzymes in the pony and dog after carbon tetrachloride administration","volume":"42","author":"Noonan N. E.","year":"1981","journal-title":"Am. J. Vet. Res."},{"volume-title":"Drug Reactions and the Liver","year":"1981","author":"Thomann R.","key":"e_1_2_1_7_2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367784780891217"},{"issue":"2","key":"e_1_2_1_9_2","first-page":"107","article-title":"Assessment of local irritancy of drugs in rats after intramuscular injection","volume":"111","author":"Burnett S.","year":"1981","journal-title":"Int. J. Tiss. React."},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","unstructured":"C. W.Davy A.Brock D. A.EichlerandJ. M.Walker Tissue levels of enzymes of diagnostic interest in the marmoset.J. Comp. Pathol.In Press (1988).","DOI":"10.1016\/0021-9975(88)90103-X"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/036985646200200107"},{"volume-title":"Handbook of Enzyme Electrophoresis in Human Genetics","year":"1976","author":"Harris H.","key":"e_1_2_1_12_2"},{"volume-title":"Guidelines for Detection of Hepatotoxicity due to Drugs and Chemicals","year":"1981","author":"Davidson C. S.","key":"e_1_2_1_13_2"},{"key":"e_1_2_1_14_2","first-page":"99","article-title":"Patterns of enzyme activity in liver, other organs and serum of marmosets compared to man and other animals","volume":"12","author":"Mohr J. R.","year":"1971","journal-title":"Enzyme"},{"key":"e_1_2_1_15_2","first-page":"138","volume-title":"Methods of Enzymatic Analysis","author":"Henderson A. R.","year":"1983"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367787780740725"},{"key":"e_1_2_1_17_2","first-page":"161","article-title":"Experimental hepatitis","volume":"12","author":"Mohr J. R.","year":"1971","journal-title":"Enzyme"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/clinchem\/30.1.101","article-title":"Stabilities of some constituents of marmoset (Callithrix jacchus) plasma under various conditions of storage","volume":"30","author":"Davy C. W.","year":"1984","journal-title":"Clin. Chem."},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5250.493"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(25)07129-7","article-title":"Carbon tetrachloride hepatotoxicity","volume":"19","author":"Recknagel R. O.","year":"1967","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(74)90253-1"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300306"},{"first-page":"311","volume-title":"Latogenic Diseases","author":"Bourke J. B.","key":"e_1_2_1_23_2"},{"key":"e_1_2_1_24_2","first-page":"95","article-title":"Effect of transient hypoxia in skeletal muscle on enzyme activities in lymph and plasma","volume":"20","author":"Lindena J.","year":"1982","journal-title":"J. Clin. Chem. Clin. Biochem."}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550090107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550090107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T09:08:50Z","timestamp":1760519330000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550090107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,2]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,2]]}},"alternative-id":["10.1002\/jat.2550090107"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550090107","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1989,2]]}}}