{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:35Z","timestamp":1786978055248,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5885,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1989,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Male Wistar rats were given 0.5 and 2% lead acetate in drinking water for 2 months, 1% lead acetate for 3 months and sodium acetate equimolar to 2% lead acetate for 3 months. Glucose, total proteins, lactate dehydrogenase (LDH), lysozyme and \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    \u2010microglobulin (\u03b2\n                    <jats:sub>2<\/jats:sub>\n                    \u2010m) were measured in 24\u2010h urine every month. Kidney weight and histology were also examined.\n                  <\/jats:p>\n                  <jats:p>\n                    At the three doses, lead exposure produced a significant elevation of the kidney weight. No significant change in urinary parameters was observed in rats given 0.5% lead acetate. Exposure to 1% lead acetate increased the urinary excretion of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    \u2010m only.\n                  <\/jats:p>\n                  <jats:p>\n                    At the 2% lead acetate dose the elevation of \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    \u2010m excretion was accompanied by an increased urinary output of glucose, total proteins, lysozyme and LDH. Observations of the kidneys by light microscopy were in agreement with these biochemical findings. The nephrotoxic effect of acetate was excluded by the lack of biochemical or histological effects of sodium acetate on the kidney. It is concluded that a proximal tubular dysfunction is induced in rats chronically exposed to high doses of lead.\n                  <\/jats:p>","DOI":"10.1002\/jat.2550090605","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T12:17:30Z","timestamp":1160828250000},"page":"395-399","source":"Crossref","is-referenced-by-count":18,"title":["Dose\u2010related proximal tubular dysfunction in male rats chronically exposed to lead"],"prefix":"10.1002","volume":"9","author":[{"given":"Adolf","family":"Vyskocil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Pancl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miloslav","family":"Tusl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ettlerova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Semecky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Ka\u0161parov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lauwerys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1986.9937412"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1973.73"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1966.00290130019005"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.162"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/archinte.1979.03630380035014","article-title":"Detection and treatment of occupational lead nephropathy","volume":"139","author":"Weeden R. 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