{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:55:43Z","timestamp":1760576143871,"version":"build-2065373602"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5823,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enlarged nuclei have been observed frequently as an early carcinogen\u2010induced change in both cultured cells and in target tissues <jats:italic>in vivo.<\/jats:italic> The purpose of this work was to examine the occurrence of nuclear enlargement in the upper respiratory tract of rats to provide further evidence of whether nuclear enlargement is a reliable marker of carcinogenesis, and if it could be used as a short\u2010term test for respiratory carcinogens.<\/jats:p><jats:p>Carcinogen\u2010induced nuclear enlargement is best demonstrated <jats:italic>in vivo<\/jats:italic> when\/the tissue involved has been undergoing rapid replication. Male Wistar albino rats were simultaneously exposed to an atmosphere containing sulphur dioxide (which caused a hyperplastic response in the nasal cavity) and received an i.p. injection of a nitrosamine. Sections were prepared from the nasal cavity, and the nuclear areas of respiratory epithelial cells were measured. There were some increases in nuclear size 24 and 72 h after the start of treatment. The reversal of this effect 120 h after the start of treatment may have been due to the loss of the normal ciliated mucosal epithelium, and subsequent loss of metabolic capability.<\/jats:p>","DOI":"10.1002\/jat.2550100106","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T12:27:09Z","timestamp":1160828829000},"page":"29-38","source":"Crossref","is-referenced-by-count":6,"title":["The short\u2010term effects of carcinogens and sulphur dioxide on the nuclear size of rat nasal epithelial cells"],"prefix":"10.1002","volume":"10","author":[{"given":"A. 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