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To test the age\u2010dependent sensitivity to the nephrotoxicity of dichromate, young and adult rats were given doses to achieve identical chromium conce\u00e4trations in the kidney. At equal renal concentrations, young rats had less functional and morphological damage than adult rats. As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age\u2010dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age.<\/jats:p>","DOI":"10.1002\/jat.2550100314","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T01:42:01Z","timestamp":1160962921000},"page":"227-232","source":"Crossref","is-referenced-by-count":6,"title":["Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats"],"prefix":"10.1002","volume":"10","author":[{"given":"D.","family":"Appenroth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gambaryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.\u2010H.","family":"Friese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Br\u00e4unlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"185","volume-title":"Handbook on the Toxicology of Metals","author":"Langgard S.","year":"1986"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_2","DOI":"10.1007\/978-3-642-67729-8_44"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_2","DOI":"10.1016\/S0232-1513(88)80065-3"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1007\/BF02783843"},{"key":"e_1_2_1_6_2","first-page":"3188","article-title":"Prominent role of DT\u2010Diaphorase as a cellular mechanism reducing chromium (VI) and reverting its mutagenicity","volume":"45","author":"De Flore S.","year":"1985","journal-title":"Cancer Res."},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1016\/0006-291X(86)91168-X"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_2","DOI":"10.1172\/JCI104917"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_2","DOI":"10.1016\/S0162-0134(00)80286-X"},{"doi-asserted-by":"publisher","key":"e_1_2_1_10_2","DOI":"10.1016\/0163-7258(82)90007-9"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_2","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0021-9258(18)73708-3","article-title":"A new coupling component for sulfonamide determination","volume":"128","author":"Bratton A. 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