{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:42:56Z","timestamp":1760575376908,"version":"build-2065373602"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5520,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The compound 2\u2010chloro\u20104\u2010acetotoluidide (CAT) is highly toxic to many avian species, including the starling. In our earlier work, we demonstrated the covalent binding of radioactivity from [<jats:sup>14<\/jats:sup>C]\u2010CAT to liver and kidneys of the starling. In the present study, the effects of inducers of mixed\u2010function oxidase (MFO) and non\u2010protein sulfhydryl (NPSH) depletor on the total and covalent binding of [<jats:sup>14<\/jats:sup>C]\u2010CAT radioactivity to liver and kidney of the starling were examined. The total and covalently bound radioactivity from [<jats:sup>14<\/jats:sup>C]\u2010CAT to liver and kidney were decreased significantly in the starling pretreated with the MFO inducer, 3\u2010methylcholanthrene. However, pretreatment with phenobarbitaf, another inducer of MFO, had no effect. Pretreatment with the inhibitor of MFO, SKF 525\u2010A, reduced the covalent binding of [<jats:sup>14<\/jats:sup>C]\u2010CAT radioactivity to liver but not to kidney. There was no reduction in the NPSH content of liver or kidney following intravenous administration of CAT (3.5 mg kg<jats:sup>\u22121<\/jats:sup>). Reduction of NPSH levels in the liver or kidney following treatment with diethyl maleate caused a significant increase, in the covaient binding of [<jats:sup>14<\/jats:sup>C]\u2010CAT to kidney but not to liver.<\/jats:p>","DOI":"10.1002\/jat.2550100609","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T12:29:50Z","timestamp":1160828990000},"page":"429-438","source":"Crossref","is-referenced-by-count":2,"title":["Role of mixed\u2010function oxidases and non\u2010protein sulfhydryl contentent in [<sup>14<\/sup>C]\u20102\u2010chloro\u20104\u2010acetotoluidide binding to liver and kidney in starlings"],"prefix":"10.1002","volume":"10","author":[{"given":"Shri N.","family":"Giri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(78)90083-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(83)90051-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0090-9556(25)06079-9","article-title":"N\u2010Hydroxylation of phenoacetin by hamster liver microsomes","volume":"4","author":"Hinson J. 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