{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:37Z","timestamp":1786978057559,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5338,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    To assess the osteopenia induced by environmental cadmium (Cd) exposure by measurement of serum bone Gla protein (BGP), parathyroid hormone ((PTH) and 1\u03b1,25\u2010dihydroxyvitamin D (1\u03b1, 25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D), 29 men and 41 women who lived in a Cd\u2010polluted area and showed renal tubular dysfunction were selected. To evaluate the degree of osteopenia, microdensitometry (MD) was used. Compared with the non\u2010exposed subjects, the levels of serum creatinine and BGP, urinary Cd and \u03b2\n                    <jats:sub>2<\/jats:sub>\n                    \u2010microglobulin and blood Cd were higher, while the levels of serum inorganic phosphorus and MD indicators were lower in the Cd\u2010exposed group. In simple correlation matrix, BGP showed significant correlations with serum alkaline phosphatase (S\u2010Al\u2010p) and MD indicators in the Cd\u2010exposed men, and also correlations with S\u2010Al\u2010p and 1\u03b1\u201025(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D in the Cd\u2010exposed women.\n                  <\/jats:p>\n                  <jats:p>Applying multivariate analysis to the Cd\u2010exposed subjects, BGP, %TRP and base excess were found to show significant associations with the MD indicators in the men. In the women, PTH, age, blood Cd and BGP were associated significantly with the MD indicators.<\/jats:p>\n                  <jats:p>Only serum BGP showed a significant correlation in both sexes of the Cd\u2010exposed subjects, and a sex difference was found in the relationship between bone metabolic markers and osteopenia.<\/jats:p>\n                  <jats:p>\n                    These results suggest that serum BGP has a close independent association with the osteopenia induced by Cd exposure and that BGP, which has a different biological function from that of PTH or 1\u03b1,25(OH)\n                    <jats:sub>2<\/jats:sub>\n                    D, may be a useful indicator to detect bone damage in Cd\u2010exposed subjects.\n                  <\/jats:p>","DOI":"10.1002\/jat.2550110303","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T02:27:19Z","timestamp":1160965639000},"page":"161-166","source":"Crossref","is-referenced-by-count":15,"title":["Assessment of cadmium\u2010induced osteopenia by measurement of serum bone gla protein, parathyroid hormone, and 1\u03b1,25\u2010dihydroxyvitamin D"],"prefix":"10.1002","volume":"11","author":[{"given":"Teruhiko","family":"Kido","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryumon","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikiko","family":"Tsuritani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ishizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Dohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","volume-title":"Cadmium and Health: A Toxicological and Epidemiological Appraisal","author":"Friberg L.","year":"1986"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70856-5_3"},{"key":"e_1_2_1_4_2","volume-title":"Cadmium in the Environment","author":"Friberg L.","year":"1974"},{"key":"e_1_2_1_5_2","volume-title":"Cadmium in the Environment","author":"Nriagu J. 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