{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:41:09Z","timestamp":1760575269086,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5338,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The toxic effect of trichloroethylene (TCE) was investigated on isolated muscles prepared from frog and rats. Twitch and tetanic contractions as well as caffeine\u2010induced contractures, were recorded. Trichloroethylene at a concentration of 0.25\u20134.0 mM depressed the force development of both twitch and tetanic tension in a dose\u2010dependent manner. This effect was not influenced by the type of muscle. As TCE shortened the time to peak of twitch contractions, it may alter the Ca<jats:sup>2+<\/jats:sup> binding kinetics.<\/jats:p><jats:p>Subthreshold caffeine concentrations applied after pre\u2010exposure to TCE (1 or 2mM) induced contractures. The same TCE exposure enhanced regular caffeine contractures through increasing the speed of tension development and the absolute force. Exposure to 5 or 10 mM TCE did not affect the first caffeine\u2010induced contracture but enhanced the potency of the second caffeine dose given 15 min after the first. The results suggest that the interaction of TCE with membrane sites is responsible for Ca<jats:sup>2+<\/jats:sup> release for contractile processes.<\/jats:p>","DOI":"10.1002\/jat.2550110306","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T02:27:19Z","timestamp":1160965639000},"page":"189-194","source":"Crossref","is-referenced-by-count":3,"title":["Trichloroethylene interactions with muscle cells"],"prefix":"10.1002","volume":"11","author":[{"given":"F.","family":"K\u00f6ssler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287397709529469"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.2635"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/29.3.391"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90108-0"},{"key":"e_1_2_1_6_2","first-page":"237","volume-title":"Safety and Health Aspects of Organic Solvents","author":"Wennberg A.","year":"1986"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(88)90018-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.26.040186.002505"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1987.tb01806.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1987.9935812"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(88)90183-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287398209530197"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-71248-7_1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(88)90025-2"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/01480548809038652"},{"key":"e_1_2_1_16_2","first-page":"99","article-title":"Zur Wirkung homologer n\u2010Alkanole auf funktionelle Eigenschaften isolierter Skeletmuskeln","volume":"34","author":"Caffier G.","year":"1975","journal-title":"Acta Biol. Med. Germ."},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581867"},{"key":"e_1_2_1_18_2","first-page":"189","article-title":"Fatty acids decrease the muscle contraction without effects on contractile proteins","volume":"98","author":"K\u00f6ssler F.","year":"1983","journal-title":"Stud. Biophys."},{"key":"e_1_2_1_19_2","first-page":"485","article-title":"Effects of Na\u2010octanoate on potassium contractures in normal and denervated frog tonic fibres","volume":"5","author":"K\u00f6ssler F.","year":"1986","journal-title":"Gen. Physiol. Biophys."},{"key":"e_1_2_1_20_2","first-page":"45","article-title":"Depressive effects of free fatty acids on the development of tension in different muscle types","volume":"45","author":"K\u00f6ssler F.","year":"1986","journal-title":"Biomed. Biochim. Acta"},{"key":"e_1_2_1_21_2","first-page":"51","article-title":"Effects of free fatty acids on the muscle cell membrane and their possible relations to the depression of contraction","volume":"45","author":"Caffier G.","year":"1986","journal-title":"Biomed. Biochim. Acta"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","DOI":"10.1152\/ajpcell.1985.248.3.C265","article-title":"Temperature\u2010dependent physiological stability of rat skeletal muscle in vitro","volume":"248","author":"Segal S. S.","year":"1985","journal-title":"Am. J. Physiol."},{"key":"e_1_2_1_23_2","first-page":"9","article-title":"Histologische, biochemische und physiologische Charakterisierung von Muskelfasertypen","volume":"21","author":"K\u00f6ssler F.","year":"1983","journal-title":"Biol. Rundsch."},{"key":"e_1_2_1_24_2","first-page":"651","article-title":"Zur Wirkung homologer n\u2010Alkanole auf funktionelle Eigenschaften isolierter Skeletmuskeln. III. Alkohol\u2010 und Koffein\u2010Kontrakturen","volume":"32","author":"K\u00f6ssler F.","year":"1974","journal-title":"Acta Biol. Med. Germ."},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1977.57.1.71"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1139\/y87-117"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550110306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550110306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T12:18:34Z","timestamp":1760530714000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550110306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1002\/jat.2550110306"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550110306","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}