{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:58:56Z","timestamp":1760576336427,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5277,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1991,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of mixtures of parathion (PA; 5 mg kg<jats:sup>\u22121<\/jats:sup>), toxaphene (TOX; 50 mg kg<jats:sup>\u22121<\/jats:sup>) and\/or 2,4\u2010dichlorophenoxyacetic acid (2,4\u2010D; 50 mg kg<jats:sup>\u22121<\/jats:sup>) on the hepatic mixed\u2010function oxygenase (MFO) system were studied in ICR male mice (21\u201324 g) by oral intubation daily for 7 days. In general, TOX and TOX\u2010containing mixtures were found to induce the metabolism of amidopyrine (21\u201352%), aniline (58\u201372%), phenacetin (239\u2013307%), pentobarbital (104\u2013148%) and benzo[a]pyrene (143\u2013304%) in the 9000 g liver supernatants and to increase the hepatic cytochrome P\u2010450 contents (57\u201380%). Furthermore, the TOX pretreatemnt was effective in enhancing the biotransformation of PA or paraoxon (PO) in the supernatants. This enhancement was not altered significantly by 5 mM EDTA. Although TOX increased the aliesterase activity in the serum and liver homogenates and supernatants by 31\u2013158%, the activity of paraoxonase was not affected in these preparations. The TOX\u2010induced increase in the metabolism of PA or PO was, at least in part, associated with the MFO system, and paraoxonase did not have significant involvement in the increase. These findings suggest that the toxicity of the PA + TOX mixture would be lower than that of PA, as TOX has the ability to increase the biotransformation of PA, as well as of PO, and the levels of aliesterase, thereby providing a pool of non\u2010critical enzymes for the binding of PO. Because of these properties of TOX, it is anticipated that the toxicity of the PA + TOX + 2,4\u2010D mixture also would be lower than that of PA.<\/jats:p>","DOI":"10.1002\/jat.2550110404","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T02:51:01Z","timestamp":1160967061000},"page":"245-251","source":"Crossref","is-referenced-by-count":12,"title":["Metabolic aspects of the toxicology of mixtures of parathion, toxaphene and\/or 2,4\u2010D in mice"],"prefix":"10.1002","volume":"11","author":[{"given":"Arvind K.","family":"Chaturvedi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Kuntz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G. 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