{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:12:48Z","timestamp":1760541168134,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5033,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A quantitative structure\u2010toxicology (LD<jats:sub>50<\/jats:sub>) relationship for some <jats:italic>N<\/jats:italic>\u2010alkylsuccinimides is presented. The relationship is based on a small and carefully selected training set using experimental design methodology. The good predictability, an overall <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> value of 0.75, with such an approach is demonstrated. Factors such as large <jats:italic>N<\/jats:italic>\u2010alkyl groups, substitution in the aromatic ring and a long side chain between the two nitrogens are favourable for low toxicity.<\/jats:p>","DOI":"10.1002\/jat.2550120212","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T03:17:35Z","timestamp":1160968655000},"page":"143-147","source":"Crossref","is-referenced-by-count":9,"title":["Experimental design\u2010based quantitative structure\u2014toxicity relationship of some local anaesthetics using the PLS method"],"prefix":"10.1002","volume":"12","author":[{"given":"Ulf","family":"Norinder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"volume-title":"Comprehensive Medicinal Chemistry","year":"1990","author":"Sammes P. 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