{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:36:47Z","timestamp":1760575007234,"version":"build-2065373602"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":4972,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have demonstrated the importance of substitution at the 3\u2010 and 5\u2010positions of the phenyl ring in <jats:italic>N<\/jats:italic>\u2010phenylsuccinimides for the production of nephrotoxicarrts in this series of compounds. The purpose of this study was to determine if the electronic nature of the 3,5\u2010substituents is an important determinant for nephrotoxic potential. Male Fischer 344 rats (four rats per group) were administered a single intraperitoneal injection of a succinimide (0.4 or 1.0 mmol kg<jats:sup>\u22121<\/jats:sup>) or vehicle, and the renal function was monitored for 48 h. Only <jats:italic>N<\/jats:italic>\u2010(3,5\u2010dichlorophenyl)succinimide (0.4 or 1.0 mmol kg<jats:sup>\u22121<\/jats:sup>) induced marked changes in renal function. Urine volume, BUN concentration and proteinuria were increased following <jats:italic>N<\/jats:italic>\u2010(3,5\u2010dinitrophenyl)succinimide (1.0 mmol kg<jats:sup>\u22121<\/jats:sup>) treatment but other renal parameters and renal morphology were unchanged in this treatment group. These results indicate that the presence of halogen atoms atthe 3\u2010 and 5\u2010positioiis of the phenyl nag in <jats:italic>N<\/jats:italic>\u2010phenylsuccinimides is more important for nephrotoxic potential than the presence of non\u2010halogen substituents. The reason why halogen substitution is an important determinant for <jats:italic>N<\/jats:italic>\u2010phenylsuccinimide nephrotoxicity is unknown.<\/jats:p>","DOI":"10.1002\/jat.2550120311","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T03:25:16Z","timestamp":1160969116000},"page":"211-216","source":"Crossref","is-referenced-by-count":5,"title":["Renal effects of <i>N<\/i>\u2010(3,5\u2010disubstitutedphenyl)\u2010succinimides in the fischer 344 rat"],"prefix":"10.1002","volume":"12","author":[{"given":"Gary O.","family":"Rankin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vonda J.","family":"Teets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiencheng","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly W.","family":"Beers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek W.","family":"Nicoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne K.","family":"Anestis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick I.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Hubbard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.36.318"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0048-3575(79)90081-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1961.46.2755"},{"key":"e_1_2_1_5_2","unstructured":"T.Ozaki A.Fujinami S.Yamamoto K.Tanaka T.OishiandK.Nodera Pyrrolidine disinfectants for industrial products. 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