{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:37:50Z","timestamp":1785710270929,"version":"3.56.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":4850,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010eight dogs were separated into four groups of six males and six females. Acrolein (0.1% aqueous) was administered in gelatin capsules to three of these groups at dosing levels of 0.1, 0.5 and 1.5 mg kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup> based on results of a range\u2010finding study. After 4 weeks, the high dose was increased to 2 mg kg<jats:sup>\u22121<\/jats:sup> day<jats:sup>\u22121<\/jats:sup>. The fourth group received deionized water in the same number of gelatin capsules as the high\u2010dose group. Dosing was 7 days per week for 53 weeks. Blood and biochemical measurements were made pretest and at 3\u2010month intervals thereafter. At termination, all dogs were subjected to full necropsy and histological exmamination.<\/jats:p><jats:p>The major test effect noted was frequent vomiting after dosing. This was observed to be dose\u2010dependent and the frequency decreased with time, indicating an adaptive effect. One mid\u2010dose female died during the test and was diagnosed as having died of severe bronchial pneumonia, probably a result of vomitus aspiration. Serum albumin, calcium and total protein values were depressed in high\u2010dose animals throughout the study. Some variability in red blood cell parameters and coagulation times were noted but the significance of these effects was not obvious.<\/jats:p>","DOI":"10.1002\/jat.2550120504","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T12:37:07Z","timestamp":1160829427000},"page":"311-316","source":"Crossref","is-referenced-by-count":16,"title":["One\u2010year toxicity of orally administered acrolein to the beagle dog"],"prefix":"10.1002","volume":"12","author":[{"given":"Richard A.","family":"Parent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halina C.","family":"Caravello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn F.","family":"Balmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Shellenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","series-title":"NTIS PB81\u2013147951","first-page":"18","volume-title":"Information Profiles on Potential Occupational Hazards, Volume I. 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