{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:58:15Z","timestamp":1760576295836,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":4758,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Studies were conducted to examine acute hepatic and renal toxicity of dichlorobenzene (DCB) structural isomers. Male Fischer 344 (F344) rats were injected with 2, 3 or 4 mmol kg<jats:sup>\u22121<\/jats:sup> of 1,2\u2010DCB, 1,3\u2010DCB or 1,4\u2010DCB (<jats:italic>o\u2212, m\u2212, p\u2212<\/jats:italic>). Pair\u2010fed control (PFC) animals were injected (i.p.) with corn oil (1 ml kg<jats:sup>\u22121<\/jats:sup>). Hepatic and renal toxicity was quantitated 24 h after injection of DCB or vehicle. Plasma transaminase (ALT\/GPT) activity was increased (<jats:italic>P<\/jats:italic>&lt;0.05) by 1,2\u2010DCB as a function of dose administered. Centrilobular necrosis was observed in rats treated with 1,2\u2010DCB while morphology was relatively normal in rats treated with <jats:italic>m<\/jats:italic>\u2010 or <jats:italic>p<\/jats:italic>\u2010DCB. Administration of (2 or 4 mmol kg<jats:sup>\u22121<\/jats:sup>) 1,3\u2010DCB or 1,4\u2010DCB did not alter kidney weight or blood urea nitrogen (BUN) levels. Renal cortical slice accumulation of <jats:italic>p<\/jats:italic>\u2010aminohippurate (PAH) was decreased (<jats:italic>P<\/jats:italic>&lt;0.05) by (2 and 4 mmol kg<jats:sup>\u22121<\/jats:sup>) 1,3\u2010DCB and (3 and 4 mmol kg<jats:sup>\u22121<\/jats:sup>) 1,2\u2010DCB while accumulation of the cation tetraethylammonium (TEA) was decreased by 4 mmol kg<jats:sup>\u22121<\/jats:sup> 1,4\u2010DCB. (TEA). The results of these studies demonstrated that <jats:italic>ortho<\/jats:italic> substitution enhanced hepatic and renal toxicity. The results also would suggest that the liver was more sensitive than the kidney for DCB toxicity.<\/jats:p>","DOI":"10.1002\/jat.2550130103","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T03:36:59Z","timestamp":1160969819000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Acute hepatic and renal toxicity of dichlorobenzene isomers in fischer 344 rats"],"prefix":"10.1002","volume":"13","author":[{"given":"Monica A.","family":"Valentovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Anestis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.34.173.74"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1970.tb03588.x"},{"key":"e_1_2_1_4_2","first-page":"1690","article-title":"Paradichlorobenzene poisoning from insecticides","volume":"53","author":"Cotter L. H.","year":"1953","journal-title":"N. Y. J. Med."},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.68.1.160"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90010-C"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(73)90009-9"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293688"},{"key":"e_1_2_1_9_2","unstructured":"National Toxicology Program Technical Series 319. Toxicology and carcinogenesis studies of 1 4\u2010DCB (CAS no. 106\u201046\u20107) in F344 rats and B6C3F1mice (gavage studies). NIH Publication no. 87\u20102575."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(89)90117-8"},{"key":"e_1_2_1_11_2","series-title":"Series Editor","first-page":"51","volume-title":"Renal Effects of Petroleum Hydrocarbons. Advances in Modern Environmental Toxicology","author":"Mehlman M. 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