{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:18:38Z","timestamp":1790086718900,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":4699,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1993,3]]},"abstract":"Abstract<\/jats:title>1,2,4\u2010Triethylbenzene (1,2,4\u2010TEB) and 1,3,5\u2010triethylbenzene (1,3,5\u2010TEB) were administered orally to male Sprague\u2010Dawley rats. Experimental and appropriate control rats were examined electrophysiologically for motor and sensory conduction velocities (MCV and SCV), and the amplitudes of the sensory (ASAP) and muscular action potentials (AMAP), at bi\u2010weekly intervals. Oral administration of 1,2,4\u2010TEB (200 or 400 mg kg\u22121<\/jats:sup>, once daily, 4 days per week for 8 weeks) produced a time\u2010 and dose\u2010dependent decrease in MCV, SCV, AMAP and ASAP. Rats treated with 1,2,4\u2010TEB exhibited a bluish discoloration of the skin and the urine was greyish\u2010greenish.<\/jats:p>No changes in MCV, SCV, AMAP and ASAP developed in rats given 1,3,5\u2010TEB orally (200 or 400 mg kg\u22121<\/jats:sup>, daily, 4 days per week for 8 weeks).<\/jats:p>The results indicate that 1,2,4\u2010TEB is a neurotoxic isomer of TEB and that the presence of two ethyl radicals in the ortho<\/jats:italic>\u2010position on an aromatic ring could be a critical molecular arrangement resulting in chromogenic and neurotoxic properties.<\/jats:p>","DOI":"10.1002\/jat.2550130209","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T13:27:20Z","timestamp":1160832440000},"page":"123-128","source":"Crossref","is-referenced-by-count":11,"title":["Triethylbenzene\u2010induced sensorimotor neuropathy in rats"],"prefix":"10.1002","volume":"13","author":[{"given":"F.","family":"Gagnaire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Marignac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"de Ceaurriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"221","article-title":"Neurotoxic changes in rats exposed to the fragrance compound acetyl ethyl tetramethyl tetralin","volume":"1","author":"Spencer P. 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