{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:51:38Z","timestamp":1760575898012,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,2,6]],"date-time":"2006-02-06T00:00:00Z","timestamp":1139184000000},"content-version":"vor","delay-in-days":4541,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The acute pulmonary function response to graded levels of a low toxicity dust was studied in guinea pigs. Four groups of five male guinea pigs each were exposed to mean concentrations of 0, 0.25, 1.01 and 5.39 mg Foundry Hill Clay I<jats:sup>\u22121<\/jats:sup> air with mass median aerodynamic diameters of 2.6, 4.6 and 6.7 \u03bcm, respectively. There was a 15\u2010min pre\u2010exposure period to clean air, a 1\u2010h exposure to the test atmosphere and then a 1\u2010h recovery period with exposure to clean air. Concentration\u2010related changes, compared to the pre\u2010exposure period, occurred with a rapid onset in a number of parameters. Generally, the severity of observed effects increased with exposure time and, therefore, with inhaled dose. Statistically significant changes (<jats:italic>P<\/jats:italic>&lt;0.05) were observed in tidal volume, dynamic compliance, dynamic resistance, flow, pressure and minute volume during the last 15 min of exposure. The observed changes were consistent with acute bronchoconstriction. These effects reversed rapidly and there were no significant changes 1 h post\u2010exposure. These results suggest that adverse physiological responses of short duration can occur when animals are exposed via inhalation to low\u2010toxicity materials in the concentration range 0.25\u20105 mg I<jats:sup>\u22121<\/jats:sup>.<\/jats:p>","DOI":"10.1002\/jat.2550130512","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T04:23:48Z","timestamp":1160972628000},"page":"369-373","source":"Crossref","is-referenced-by-count":0,"title":["Effects of high exposure concentrations of inhaled low\u2010toxicity dust on pulmonary function in guinea pigs"],"prefix":"10.1002","volume":"13","author":[{"given":"R. K.","family":"Wolff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. H.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. L.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Dorato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,2,6]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"S. B.GrossandF. J.Vocci Hazard Evaluation Division Standard Evaluation Procedure Inhalation Toxicity Testing available from NTIS as PB89\u2010100366. USEPA Washington DC (1988)."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1089\/jam.1990.3.Suppl_1.S-169"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-61355-5_7"},{"volume-title":"Generation of Aerosols and Facilities for Exposure Experiments","year":"1981","author":"Newton G. J.","key":"e_1_2_1_5_2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1958.192.2.364"},{"key":"e_1_2_1_7_2","first-page":"170","article-title":"The physiologic response of guinea pigs to atmospheric pollutants","volume":"1","author":"Amdur M. O.","year":"1959","journal-title":"Int. J. Air Pollut."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1966.10664472"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/00028896409342550"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0013-9351(78)90122-6"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/15298667991430145"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(83)90277-6"},{"key":"e_1_2_1_13_2","unstructured":"W. C.Hinds Aerosol Technology pp.233\u2013239 New York (1982)."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(92)90130-A"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/32.inhaled_particles_VI.53"},{"key":"e_1_2_1_16_2","first-page":"59","article-title":"Acute inhalation studies with an amorphous silicon dioxide dust","volume":"2","author":"Scott J. B.","year":"1982","journal-title":"Toxicologist"},{"volume-title":"A 4\u2010h Acute Inhalation Exposure to a Solid Particulate Aerosol of Foundry Hill Clay in the Fisher 344 Rat","year":"1988","author":"Wolff R. K.","key":"e_1_2_1_17_2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/138.1.129"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjat.2550130512","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.2550130512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:13:22Z","timestamp":1760541202000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.2550130512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/jat.2550130512"],"URL":"https:\/\/doi.org\/10.1002\/jat.2550130512","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"type":"print","value":"0260-437X"},{"type":"electronic","value":"1099-1263"}],"subject":[],"published":{"date-parts":[[1993,9]]}}}