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The incubation mixtures for the measurement of reductive metabolites of halothane consisted of liver microsomal suspensions, 3 mM NADPH, extract solution of Gomisi and halothane in 0.1 M potassium phosphate buffer (pH 7.4). The production of CDE and CTE was inhibited by Gomisi in a dose\u2010dependent way. The production were reduced to half in the presence of 0.5% Gomisi extract in the reaction mixture. The results suggest that Gomisi can inhibit the reductive metabolism of halothane <jats:italic>in vitro<\/jats:italic>; thus it may protect against halothane\u2010induced hepatitis.<\/jats:p>","DOI":"10.1002\/jat.2550130604","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T04:19:55Z","timestamp":1160972395000},"page":"385-388","source":"Crossref","is-referenced-by-count":3,"title":["Inhibitory effect of gomisi on reductive metabolism of halothane"],"prefix":"10.1002","volume":"13","author":[{"given":"Ni","family":"Jiaxiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohyu","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osafumi","family":"Yuge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"144","volume-title":"Postoperative Hepatic Dysfunction. 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