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The increase in the blood concentration of carbon disulphide was dose dependent after the oral administration of 100\u2013400 mg of disulfiram. Free carbon disulphide peaked at 12 h while the protein\u2010bound fraction increased at least up to 24 h. Both single (100\u2013400 mg p.o.) and repeated (200 mg daily p.o. for ca. 1 month) administrations failed to inhibit the activity of serum dopamine\u2010\u03b2\u2010hydroxylase. The repeated daily administration of 200 mg of disulfiram also had no influence on copper\u2010activated serum dopamine\u2010\u03b2\u2010hydroxylase, which was the same before and after 1\u2010month treatment period. Contrary to the disulfiram group, the activity of the copper\u2010activated enzyme in the serum of abstinent alcoholics declined significantly during the same 30 days.<\/jats:p>","DOI":"10.1002\/jat.2550140203","type":"journal-article","created":{"date-parts":[[2006,10,14]],"date-time":"2006-10-14T12:50:25Z","timestamp":1160830225000},"page":"77-80","source":"Crossref","is-referenced-by-count":3,"title":["Effects of disulfiram on serum Dopamine\u2010\u03b2\u2010hydroxylase and blood carbon disulphide concentrations in alcoholics"],"prefix":"10.1002","volume":"14","author":[{"given":"Stefano","family":"Caroldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola De","family":"Paris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Zotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilia","family":"Zanella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Brugnone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90534-K"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.134.4.371"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5628.407"},{"key":"e_1_2_1_5_2","first-page":"220","article-title":"Exposure to carbon disulphide and ischaemic heart disease in a viscose rayon factory","volume":"44","author":"Sweetnam P. 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